Wang Huifen, Zhang Yanli, Liu Zhaolan, Zhang Yin, Zhao Hongchuan, Du Shiyu
Department of Gastroenterology, China-Japan Friendship Hospital, Beijing University of Chinese Medicine, Beijing, People's Republic of China.
Center for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, People's Republic of China.
Drug Des Devel Ther. 2015 Sep 24;9:5159-68. doi: 10.2147/DDDT.S84092. eCollection 2015.
Interleukin-17 (IL-17) is a family of emerged pro-inflammatory cytokines. The IL-17A and IL-17F are two important members of IL-17 family. Previous studies have shown that the functional IL-17A G-197A and IL-17F 7488T/C polymorphisms may contribute to susceptibility to cancer but the results were inconclusive. This meta-analysis was performed to determine the exact association between IL-17 polymorphisms and cancer risk.
Online databases were searched to identify eligible case-control studies. Pooled odds ratios (ORs) and confidence intervals (CIs) were calculated by fixed-effect models or random-effect models. Publication bias was detected by Egger's test and Begg's test.
Nine eligible case-control studies of IL-17A G-197A and seven studies of IL-17F 7488T/C, including 3,181 cases and 4,005 controls, were identified. Pooled analysis suggested the variant IL-17A-197A allele was associated with increased risk cancer (GA/AA vs GG, OR =1.27, 95% CI: 1.15, 1.41, P heterogeneity =0.374; and A vs G, OR =1.30, 95% CI: 1.17, 1.45, P heterogeneity =0.021). For IL-17F 7488T/C, the homozygote 7488CC genotype significantly increased risk of cancer (CC vs TC/TT, OR =1.36, 95% CI: 0.97, 1.91, P heterogeneity =0.875; and CC vs TT, OR =1.39, 95% CI: 1.03, 1.88, P heterogeneity =0.979), especially for gastric cancer.
The variant IL-17A-197A allele and IL-17F 7488CC genotype were associated with increased risk of cancer, especially for gastric cancer.
白细胞介素-17（IL-17）是一类新出现的促炎细胞因子。IL-17A和IL-17F是IL-17家族的两个重要成员。既往研究表明，功能性IL-17A基因G-197A多态性和IL-17F基因7488T/C多态性可能与癌症易感性有关，但结果尚无定论。本荟萃分析旨在确定IL-17基因多态性与癌症风险之间的确切关联。
通过检索在线数据库来识别符合条件的病例对照研究。采用固定效应模型或随机效应模型计算合并比值比（OR）和置信区间（CI）。采用Egger检验和Begg检验检测发表偏倚。
共纳入9项关于IL-17A基因G-197A的符合条件的病例对照研究以及7项关于IL-17F基因7488T/C的研究，包括3181例病例和对照4005例。合并分析表明，IL-17A基因-197A变异等位基因与癌症风险增加相关（GA/AA与GG相比，OR = 1.27，95%CI：1.15，1.41，P异质性 = 0.374；A与G相比，OR = 1.30，95%CI：1.17，1.45，P异质性 = 0.021）。对于IL-17F基因7488T/C，纯合子7488CC基因型显著增加癌症风险（CC与TC/TT相比，OR = 1.36，95%CI：0.97，1.91，P异质性 = 0.875；CC与TT相比，OR = 1.39，95%CI：1.03，1.88，P异质性 = 0.979），尤其是对于胃癌。
IL-17A基因-197A变异等位基因和IL-17F基因7488CC基因型与癌症风险增加相关，尤其是对于胃癌。
