Universidad Señor de Sipan, Chiclayo, Peru.
Unidad Academica de Estudios Nucleares, Universidad Autonoma de Zacatecas, Zacatecas, Zac, Mexico.
Appl Radiat Isot. 2021 Oct;176:109888. doi: 10.1016/j.apradiso.2021.109888. Epub 2021 Aug 4.
MIRD method with the Stabin/Segars anthropomorphic representations were used to calculate the absorbed doses in kidneys and uterine wall of an early-stage pregnant woman when Tc (DTPA), Tc (DMSA) and Tc (MAG3) are used for renal studies. Stabin and Segars anatomical representations are phantoms that are used in Monte Carlo calculations to determine the SAF, that with the pharmaceutical residence time are used to calculate the absorbed dose, from source organs, on target organs. Concerns about the impact on the absorbed dose due to the use of the three Tc-based compounds as well as the use of different phantoms were here treated for the case of a female at early pregnant state. The lowest absorbed dose in the kidneys was obtained with Tc (MAG3), and the relative difference of using Stabin and Segars anthropomorphic representations was 2.5%. For bladder and rest of organs the relative difference 14.63%. The lowest absorbed dose by uterine wall was obtained with Tc(DMSA), however the relative difference of using Stabin and Segars anthropomorphic representations was 12%.
使用 MIRD 方法和 Stabin/Segars 人体模型,计算了 Tc(DTPA)、Tc(DMSA)和 Tc(MAG3)用于肾脏研究时早期孕妇肾脏和子宫壁的吸收剂量。Stabin 和 Segars 解剖模型是用于蒙特卡罗计算的体模,用于确定 SAF,结合药物停留时间用于计算源器官对靶器官的吸收剂量。本文考虑了在早期妊娠女性中,使用三种基于 Tc 的化合物以及使用不同体模对吸收剂量的影响。Tc(MAG3)在肾脏中产生的吸收剂量最低,使用 Stabin 和 Segars 人体模型的相对差异为 2.5%。对于膀胱和其他器官,相对差异为 14.63%。Tc(DMSA)在子宫壁中产生的吸收剂量最低,但使用 Stabin 和 Segars 人体模型的相对差异为 12%。