Ghodse A H
St. George's Hospital, London, U.K.
Drug Alcohol Depend. 1987 Dec;20(4):375-83. doi: 10.1016/0376-8716(87)90010-x.
Epidemiological information on the abuse of opioid agonist-antagonists is scanty. Most of the available information relates to pentazocine, the 'oldest' of this class of drugs, and it appears that a sporadic episode of its intravenous abuse in several cities in the United States, is subsiding: reformulation of pentazocine tablets to contain naloxone may have contributed to the decline in this abuse. Apart from a few reports of buprenorphine abuse, there are only occasional accounts of abuse of other drugs in this class. However, the lack of data does not necessarily mean that abuse does not occur and it is essential that epidemiologically sound investigations should be made to explore the existence and extent of any such problem. The interpretation of epidemiological data relating to agonist-antagonist abuse is discussed.
关于阿片类激动剂 - 拮抗剂滥用的流行病学信息很少。现有的大部分信息都与喷他佐辛有关，它是这类药物中“最古老”的一种，在美国几个城市中，其静脉注射滥用的零星事件似乎正在减少：将喷他佐辛片剂重新配方使其含有纳洛酮可能促成了这种滥用现象的减少。除了一些关于丁丙诺啡滥用的报告外，这类药物中其他药物的滥用仅有偶尔的报道。然而，数据的缺乏并不一定意味着滥用不存在，必须进行符合流行病学规范的调查，以探究任何此类问题的存在及其程度。本文讨论了与激动剂 - 拮抗剂滥用相关的流行病学数据的解读。
