Kaaber K, Menne T, Veien N K, Baadsgaard O
Dermatology Clinic, Herning, Denmark.
Derm Beruf Umwelt. 1987 Nov-Dec;35(6):209-11.
A retrospective follow-up study is reported of 58 women and 3 men with nickel allergy and hand eczema, of at least 4 months duration, treated with 50 to 400 mg disulfiram per day for 4 to 56 weeks. 2 patients were given 2 treatment series, making a total of 63 treatment series. 11 patients (20%) developed biochemical evidence of hepatotoxicity. 5 of them developed clinical evidence of hepatitis, which, for 4, was verified by liver biopsy. The patients with hepatotoxcity were significantly older than those who did not have this side effect. No correlation could be seen between the cumulative or maximum dose of disulfiram, the duration of the therapy and whether or not the patients showed evidence of hepatotoxicity. In 29 treatment series the dermatitis healed, while improvement was seen in 19 and no change in 15. There was no difference in the results whether maximum daily doses of 50, 200 or 400 mg were given. Follow-up examinations showed that the eczema recurred within a month after termination of therapy in 50% of the patients who improved during disulfiram therapy. Recurrence was seen within 6 months for another 40% of the patients.
报告了一项回顾性随访研究，研究对象为58名女性和3名男性，他们患有镍过敏和手部湿疹，病程至少4个月，每天服用50至400毫克双硫仑，持续4至56周。2名患者接受了2个疗程的治疗，总共63个疗程。11名患者（20%）出现了肝毒性的生化证据。其中5名患者出现了肝炎的临床证据，4名患者经肝活检证实。出现肝毒性的患者明显比未出现这种副作用的患者年龄大。双硫仑的累积剂量或最大剂量、治疗持续时间与患者是否出现肝毒性证据之间未见相关性。在29个疗程中，皮炎治愈，19个疗程有改善，15个疗程无变化。给予每日最大剂量50、200或400毫克时，结果无差异。随访检查显示，在双硫仑治疗期间病情改善的患者中，50%在治疗结束后1个月内湿疹复发。另外40%的患者在6个月内复发。
