Kaaber K, Menne T, Tjell J C, Veien N
Contact Dermatitis. 1979 Jul;5(4):221-8. doi: 10.1111/j.1600-0536.1979.tb04855.x.
Eleven nickel-hypersensitive patients with chronic, dyshidrotic hand eczema aggravated by oral challenge with 0.6-2.5 mg nickel were treated with 100 mg tetraethylthiuramdisulfide (Antabuse) two to four times daily for 4-10 weeks. Nine of the patients experienced a flare of the dermatitis shortly after initiation of the treatment. During the course of treatment the dermatitis of seven patients cleared, improvement was seen in two patients, and in two the dermatitis remained unchanged. Flare was seen in six patients when the treatment was discontinued. Seven patients experienced side effects such as fatigue, headache and dizziness. The treatment of four patients was discontinued due to side effects. During the treatment high levels of nickel were found in the serum and urine.
11名对镍过敏的慢性汗疱疹样手部湿疹患者，口服0.6 - 2.5毫克镍会加重病情，他们每日服用2至4次100毫克二硫化四乙秋兰姆（戒酒硫），持续4至10周。9名患者在治疗开始后不久出现了皮炎发作。在治疗过程中，7名患者的皮炎消退，2名患者病情改善，2名患者的皮炎无变化。停药后，6名患者出现了病情发作。7名患者出现了疲劳、头痛和头晕等副作用。4名患者因副作用而停止治疗。治疗期间，在血清和尿液中发现了高含量的镍。
