Kojima S, Jay M
Department of Radiopharmacy, School of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan.
Eur J Nucl Med. 1987;13(9):474-7. doi: 10.1007/BF00281863.
We have reported that Pisum sativum agglutinin (PSA), a plant lectin which recognizes mannosyl residues, accumulates markedly in Ehrlich solid tumor (EST) and suggested the possibility of applying PSA to tumor imaging radiopharmaceuticals. In the present work, an inflammation was induced by implantation of cotton thread in the left rear leg skeletal muscle of ddY mice and Ehrlich ascites tumor cells were inoculated into the right rear leg. 67Ga-citrate accumulated in the tumor tissue and the inflammatory lesion to almost equal extents. On the other hand, 125I-PSA preferentially accumulated in tumor tissues in mice bearing both tumor and inflammation. The results suggest that differential diagnosis of tumor from inflammation using radiolabeled PSA may be possible.
我们曾报道，豌豆凝集素（PSA）是一种识别甘露糖基残基的植物凝集素，在艾氏实体瘤（EST）中显著蓄积，并提出了将PSA应用于肿瘤显像放射性药物的可能性。在本研究中，通过在ddY小鼠左后肢骨骼肌植入棉线诱导炎症，并将艾氏腹水瘤细胞接种到右后肢。柠檬酸镓在肿瘤组织和炎症病变中的蓄积程度几乎相同。另一方面，125I-PSA在同时患有肿瘤和炎症的小鼠的肿瘤组织中优先蓄积。结果表明，使用放射性标记的PSA对肿瘤与炎症进行鉴别诊断是可能的。
