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1
Notice of Retraction: Acharya P, Chen J-J, Correia MA (2010) Hepatic heme-regulated inhibitor (HRI) eukaryotic initiation factor 2 kinase: a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone. 77():575-592; doi:10.1124/mol.109.061259.撤稿通知：阿查里亚P、陈J-J、科雷亚MA（2010年）肝脏血红素调节抑制剂（HRI）真核起始因子2激酶：血红素介导的CYP2B酶翻译控制的主角及基础内质网应激状态的调节剂。77():575 - 592；doi:10.1124/mol.109.061259
Mol Pharmacol. 2021 Aug;100(2):65. doi: 10.1124/mol.109.061259retraction.
2
Hepatic heme-regulated inhibitor (HRI) eukaryotic initiation factor 2alpha kinase: a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone.肝血红素调节抑制剂（HRI）真核起始因子 2α 激酶：血红素介导的 CYP2B 酶翻译控制的主角和基础内质网应激紧张的调节剂。
Mol Pharmacol. 2010 Apr;77(4):575-92. doi: 10.1124/mol.109.061259. Epub 2010 Jan 13.
3
Notice of Retraction: Acharya P, Engel JC, Correia MA (2009) Hepatic CYP3A suppression by high concentrations of proteasomal inhibitors: A consequence of endoplasmic reticulum (ER) stress induction, activation of RNA-dependent protein kinase-like ER-bound eukaryotic initiation factor 2 (eIF2)-kinase (PERK) and general control nonderepressible-2 eIF2 kinase (GCN2), and global translational shutoff. 76():503-515; DOI: https://doi.org/10.1124/mol.109.056002.撤稿通知：阿查里亚P、恩格尔JC、科雷亚MA（2009年）高浓度蛋白酶体抑制剂对肝脏CYP3A的抑制作用：内质网（ER）应激诱导、RNA依赖性蛋白激酶样内质网结合真核起始因子2（eIF2）激酶（PERK）和一般控制非抑制性2 eIF2激酶（GCN2）的激活以及整体翻译关闭的结果。76():503 - 515；DOI: https://doi.org/10.1124/mol.109.056002
Mol Pharmacol. 2021 Aug;100(2):82. doi: 10.1124/mol.109.056002retraction.
4
Translation initiation control by heme-regulated eukaryotic initiation factor 2alpha kinase in erythroid cells under cytoplasmic stresses.细胞质应激条件下，血红素调节的真核起始因子2α激酶对红细胞中翻译起始的调控
Mol Cell Biol. 2001 Dec;21(23):7971-80. doi: 10.1128/MCB.21.23.7971-7980.2001.
5
Two heme-binding domains of heme-regulated eukaryotic initiation factor-2alpha kinase. N terminus and kinase insertion.血红素调节的真核起始因子-2α激酶的两个血红素结合结构域。N端和激酶插入区。
J Biol Chem. 2000 Feb 18;275(7):5171-8. doi: 10.1074/jbc.275.7.5171.
6
In situ phosphorylation of the alpha subunit of eukaryotic initiation factor 2 in reticulocyte lysates inhibited by heme deficiency, double-stranded RNA, oxidized glutathione, or the heme-regulated protein kinase.网织红细胞裂解液中真核起始因子2的α亚基的原位磷酸化受到血红素缺乏、双链RNA、氧化型谷胱甘肽或血红素调节蛋白激酶的抑制。
Proc Natl Acad Sci U S A. 1979 May;76(5):2118-22. doi: 10.1073/pnas.76.5.2118.
7
Activation of heme-regulated eukaryotic initiation factor 2alpha kinase by nitric oxide is induced by the formation of a five-coordinate NO-heme complex: optical absorption, electron spin resonance, and resonance raman spectral studies.一氧化氮通过形成五配位的NO-血红素复合物诱导血红素调节的真核起始因子2α激酶的激活：光吸收、电子自旋共振和共振拉曼光谱研究。
J Biol Chem. 2004 Apr 16;279(16):15752-62. doi: 10.1074/jbc.M310273200. Epub 2004 Jan 29.
8
Heme-regulated inhibitor kinase-mediated phosphorylation of eukaryotic translation initiation factor 2 inhibits translation, induces stress granule formation, and mediates survival upon arsenite exposure.血红素调节抑制激酶介导的真核翻译起始因子2磷酸化可抑制翻译、诱导应激颗粒形成并介导亚砷酸盐暴露后的细胞存活。
J Biol Chem. 2005 Apr 29;280(17):16925-33. doi: 10.1074/jbc.M412882200. Epub 2005 Jan 31.
9
Phosphorylation of a heme-regulated eukaryotic initiation factor 2α kinase enhances the interaction with heat-shock protein 90 and substantially upregulates kinase activity.血红素调节的真核起始因子2α激酶的磷酸化增强了与热休克蛋白90的相互作用，并显著上调激酶活性。
Protein Pept Lett. 2011 Dec;18(12):1251-7. doi: 10.2174/092986611797642733.
10
The heme-regulated inhibitor kinase requires dimerization for heme-sensing activity.亚铁血红素调节抑制剂激酶需要二聚化才能发挥血红素感应活性。
J Biol Chem. 2022 Oct;298(10):102451. doi: 10.1016/j.jbc.2022.102451. Epub 2022 Sep 3.

Notice of Retraction: Acharya P, Chen J-J, Correia MA (2010) Hepatic heme-regulated inhibitor (HRI) eukaryotic initiation factor 2 kinase: a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone. 77():575-592; doi:10.1124/mol.109.061259.

出版信息

Mol Pharmacol. 2021 Aug;100(2):65. doi: 10.1124/mol.109.061259retraction.

DOI:10.1124/mol.109.061259retraction
PMID:34404736
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8382259/
Abstract
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