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1
Notice of Retraction: Acharya P, Engel JC, Correia MA (2009) Hepatic CYP3A suppression by high concentrations of proteasomal inhibitors: A consequence of endoplasmic reticulum (ER) stress induction, activation of RNA-dependent protein kinase-like ER-bound eukaryotic initiation factor 2 (eIF2)-kinase (PERK) and general control nonderepressible-2 eIF2 kinase (GCN2), and global translational shutoff. 76():503-515; DOI: https://doi.org/10.1124/mol.109.056002.撤稿通知：阿查里亚P、恩格尔JC、科雷亚MA（2009年）高浓度蛋白酶体抑制剂对肝脏CYP3A的抑制作用：内质网（ER）应激诱导、RNA依赖性蛋白激酶样内质网结合真核起始因子2（eIF2）激酶（PERK）和一般控制非抑制性2 eIF2激酶（GCN2）的激活以及整体翻译关闭的结果。76():503 - 515；DOI: https://doi.org/10.1124/mol.109.056002
Mol Pharmacol. 2021 Aug;100(2):82. doi: 10.1124/mol.109.056002retraction.
2
Hepatic CYP3A suppression by high concentrations of proteasomal inhibitors: a consequence of endoplasmic reticulum (ER) stress induction, activation of RNA-dependent protein kinase-like ER-bound eukaryotic initiation factor 2alpha (eIF2alpha)-kinase (PERK) and general control nonderepressible-2 eIF2alpha kinase (GCN2), and global translational shutoff.高浓度蛋白酶体抑制剂对肝脏CYP3A的抑制作用：内质网（ER）应激诱导、RNA依赖性蛋白激酶样内质网结合真核起始因子2α（eIF2α）激酶（PERK）和一般控制非抑制性2 eIF2α激酶（GCN2）激活以及整体翻译关闭的结果
Mol Pharmacol. 2009 Sep;76(3):503-15. doi: 10.1124/mol.109.056002. Epub 2009 Jun 11.
3
Notice of Retraction: Acharya P, Chen J-J, Correia MA (2010) Hepatic heme-regulated inhibitor (HRI) eukaryotic initiation factor 2 kinase: a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone. 77():575-592; doi:10.1124/mol.109.061259.撤稿通知：阿查里亚P、陈J-J、科雷亚MA（2010年）肝脏血红素调节抑制剂（HRI）真核起始因子2激酶：血红素介导的CYP2B酶翻译控制的主角及基础内质网应激状态的调节剂。77():575 - 592；doi:10.1124/mol.109.061259
Mol Pharmacol. 2021 Aug;100(2):65. doi: 10.1124/mol.109.061259retraction.
4
p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity.p58IPK是真核起始因子2α激酶GCN2的一种抑制剂，其定位和表达是蛋白质合成及内质网加工能力的基础。
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The PERK Arm of the Unfolded Protein Response Negatively Regulates Transmissible Gastroenteritis Virus Replication by Suppressing Protein Translation and Promoting Type I Interferon Production.未折叠蛋白反应的 PERK 臂通过抑制蛋白翻译和促进 I 型干扰素产生来负调控传染性胃肠炎病毒复制。
J Virol. 2018 Jul 17;92(15). doi: 10.1128/JVI.00431-18. Print 2018 Aug 1.
6
PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway.PERK和GCN2在未折叠蛋白反应途径激活后促进eIF2α磷酸化和细胞周期停滞。
Mol Biol Cell. 2005 Dec;16(12):5493-501. doi: 10.1091/mbc.e05-03-0268. Epub 2005 Sep 21.
7
The role of nitric-oxide synthase in the regulation of UVB light-induced phosphorylation of the alpha subunit of eukaryotic initiation factor 2.一氧化氮合酶在紫外线B光诱导的真核起始因子2α亚基磷酸化调节中的作用
J Biol Chem. 2009 Sep 4;284(36):24281-8. doi: 10.1074/jbc.M109.008821. Epub 2009 Jul 8.
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Pollen Typhae Total Flavone Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis in Human Aortic-Vascular Smooth Muscle Cells through Down-Regulating PERK-eIF2α-ATF4-CHOP Pathway.蒲黄总黄酮通过下调 PERK-eIF2α-ATF4-CHOP 通路抑制内质网应激诱导的人主动脉血管平滑肌细胞凋亡。
Chin J Integr Med. 2019 Aug;25(8):604-612. doi: 10.1007/s11655-019-3052-4. Epub 2019 Feb 1.
9
Control of PERK eIF2alpha kinase activity by the endoplasmic reticulum stress-induced molecular chaperone P58IPK.内质网应激诱导分子伴侣P58IPK对PERK eIF2α激酶活性的调控
Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):15920-5. doi: 10.1073/pnas.252341799. Epub 2002 Nov 22.
10
Functional characterization of Drosophila melanogaster PERK eukaryotic initiation factor 2alpha (eIF2alpha) kinase.黑腹果蝇PERK真核起始因子2α（eIF2α）激酶的功能特性
Eur J Biochem. 2003 Jan;270(2):293-306. doi: 10.1046/j.1432-1033.2003.03383.x.

Notice of Retraction: Acharya P, Engel JC, Correia MA (2009) Hepatic CYP3A suppression by high concentrations of proteasomal inhibitors: A consequence of endoplasmic reticulum (ER) stress induction, activation of RNA-dependent protein kinase-like ER-bound eukaryotic initiation factor 2 (eIF2)-kinase (PERK) and general control nonderepressible-2 eIF2 kinase (GCN2), and global translational shutoff. 76():503-515; DOI: https://doi.org/10.1124/mol.109.056002.

出版信息

Mol Pharmacol. 2021 Aug;100(2):82. doi: 10.1124/mol.109.056002retraction.

DOI:10.1124/mol.109.056002retraction
PMID:34404737
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8382260/
Abstract
摘要