多种蛋白激酶C激活剂对离体豚鼠心房的变力性和变时性差异效应。
Differential inotropic and chronotropic effects of various protein kinase C activators on isolated guinea pig atria.
作者信息
Teutsch I, Weible A, Siess M
机构信息
Pharmakologisches Institut, Universität Tübingen, F.R.G.
出版信息
Eur J Pharmacol. 1987 Dec 15;144(3):363-7. doi: 10.1016/0014-2999(87)90389-x.
1,2-Dioctanoylglycerol (10-100 microM) produced a positive inotropic effect on electrically stimulated left guinea pig atria and increased the frequency of spontaneously beating atria. Various phorbol esters and mezerein induced heterogeneous responses of the left atria. Phorbol dibutyrate and phorbol didecanoate decreased the force of contraction to different extents, whereas phorbol myristate acetate and mezerein had dual actions: an initial enhancement followed by a decline in force. None of these compounds changed the spontaneous atrial rate.
1,2 - 二辛酰甘油（10 - 100微摩尔）对电刺激的豚鼠左心房产生正性肌力作用，并增加了自发性搏动心房的频率。各种佛波酯和芫花酯素引起左心房的异质性反应。二丁酰佛波酯和二癸酰佛波酯在不同程度上降低了收缩力，而乙酸肉豆蔻佛波酯和芫花酯素具有双重作用：最初增强随后收缩力下降。这些化合物均未改变心房的自发率。
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