School of Bioengineering, Dalian University of Technology, Dalian 116024, Liaoning, China.
Department of Bioengineering, College of Life Science, Dalian Minzu University, Dalian 116600, Liaoning, China.
J Agric Food Chem. 2021 Sep 1;69(34):9822-9836. doi: 10.1021/acs.jafc.1c04194. Epub 2021 Aug 18.
Prediabetes is a prevalent metabolic disorder with multiple complications, including nonalcoholic fatty liver disease (NAFLD). In this study, we investigated the combinatorial effect of baicalein, a dietary flavonoid abundant in multiple edible plants, and acarbose on prediabetes-associated NAFLD. Baicalein and its metabolites inhibited lipogenesis (DNL), thereby decreasing lipid accumulation and hepatokine secretion in oleic acid-induced hepatocytes. Carbohydrate restriction, which mimicked the effect of acarbose, led to comparable results. The combinatorial effect of baicalein and acarbose was further verified in prediabetic mice with NAFLD. Through the 16-week intervention, baicalein and acarbose inhibited DNL and improved glucose tolerance, oxidative stress, liver histology, and hepatokine secretion, thereby ameliorating insulin resistance and NAFLD. Our study demonstrated that baicalein enhanced the effect of acarbose on improving NAFLD and explored the underlying multitarget mechanism, laying a theoretical foundation for the development of flavonoid dietary supplements for the simultaneous improvement of NAFLD and prediabetes.
糖尿病前期是一种常见的代谢紊乱疾病，伴有多种并发症，包括非酒精性脂肪性肝病（NAFLD）。在这项研究中，我们研究了膳食类黄酮白杨素与阿卡波糖联合对与糖尿病前期相关的非酒精性脂肪性肝病（NAFLD）的影响。白杨素及其代谢产物抑制了脂肪生成（DNL），从而减少了油酸诱导的肝细胞中脂质积累和细胞因子的分泌。碳水化合物限制（模拟阿卡波糖的作用）也产生了类似的结果。在糖尿病前期合并 NAFLD 的小鼠中进一步验证了白杨素和阿卡波糖的联合作用。通过 16 周的干预，白杨素和阿卡波糖抑制了 DNL，并改善了葡萄糖耐量、氧化应激、肝组织学和细胞因子分泌，从而改善了胰岛素抵抗和 NAFLD。我们的研究表明，白杨素增强了阿卡波糖改善非酒精性脂肪性肝病的效果，并探讨了潜在的多靶点机制，为开发同时改善非酒精性脂肪性肝病和糖尿病前期的黄酮类膳食补充剂奠定了理论基础。
