Division of Nephrology, 63136Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Division of Gastroenterology, 63136Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Vascular. 2022 Oct;30(5):928-933. doi: 10.1177/17085381211039941. Epub 2021 Aug 18.
Indoxyl sulfate, known for its cardiovascular toxicity, is associated with vascular and coronary artery diseases and increased mortality. Peripheral arterial disease, defined by low ankle-brachial index, is associated with increased mortality in patients on hemodialysis. The present study aimed to determine the relationship between the serum indoxyl sulfate level and peripheral arterial disease in patients on maintenance hemodialysis.
The present cross-sectional, single-center study included 75 patients on maintenance hemodialysis. Serum indoxyl sulfate levels were determined by high-performance liquid chromatography-mass spectrometry. Ankle-brachial index values were measured using an automated oscillometric device. Patients with ankle-brachial indexes of < 0.9 were categorized into the low ankle-brachial index group.
In the study cohort, 12 of the 75 patients (16.0%) had low ankle-brachial indexes. The rates of diabetes mellitus ( = 0.010) as well as the serum levels of C-reactive protein ( < 0.001) and indoxyl sulfate ( < 0.001) were higher in the low ankle-brachial index group than the normal ankle-brachial index group. The multivariable logistic regression analysis revealed that serum levels of indoxyl sulfate (odds ratio = 1.123, 95% confidence interval 1.011-1.249, = 0.031) and C-reactive protein (each 0.1 mg/dL increase, odds ratio = 1.169, 95% confidence interval 1.018-1.343, = 0.027) were independently associated with peripheral arterial disease in patients on maintenance hemodialysis.
Serum indoxyl sulfate levels were associated with peripheral arterial disease in patients on maintenance hemodialysis.
硫酸吲哚酚因其心血管毒性而与血管和冠状动脉疾病以及死亡率升高相关。踝臂指数降低定义的外周动脉疾病与血液透析患者的死亡率升高相关。本研究旨在确定维持性血液透析患者血清硫酸吲哚酚水平与外周动脉疾病之间的关系。
本横断面、单中心研究纳入了 75 名接受维持性血液透析的患者。采用高效液相色谱-质谱法测定血清硫酸吲哚酚水平。使用自动振荡测量装置测量踝臂指数值。将踝臂指数 < 0.9 的患者归入低踝臂指数组。
在研究队列中，75 名患者中有 12 名（16.0%）踝臂指数较低。低踝臂指数组的糖尿病患病率（ = 0.010）以及 C 反应蛋白（ < 0.001）和硫酸吲哚酚（ < 0.001）的血清水平均高于正常踝臂指数组。多变量逻辑回归分析显示，血清硫酸吲哚酚水平（比值比=1.123，95%置信区间 1.011-1.249， = 0.031）和 C 反应蛋白（每增加 0.1mg/dL，比值比=1.169，95%置信区间 1.018-1.343， = 0.027）与维持性血液透析患者的外周动脉疾病独立相关。
维持性血液透析患者的血清硫酸吲哚酚水平与外周动脉疾病相关。
