Chern Yahn-Bor, Tsai Jen-Pi, Hsu Bang-Gee, Liu Chin-Hung, Wang Ji-Hung
Division of Nephrology, Department of Internal Medicine, Yuan's General Hospital, Kaohsiung 80249, Taiwan.
Division of Nephrology, Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi 62247, Taiwan.
Diagnostics (Basel). 2025 Apr 25;15(9):1097. doi: 10.3390/diagnostics15091097.
-Cresyl sulfate (PCS) is implicated in inflammation, oxidative stress and vascular dysfunction. Hypertension is a major risk factor for peripheral arterial disease (PAD), which is linked to increased mortality in patients with hypertension. This study aimed to evaluate the association between serum PCS levels and PAD in hypertension cases. : We analyzed fasting blood samples and clinical data from 105 patients with hypertension in a cardiovascular outpatient clinic. Serum PCS levels were quantified using high-performance liquid chromatography-mass spectrometry. Ankle-brachial index (ABI) was measured using an automated oscillometric device; ABI < 0.9 indicated PAD. : A total of 24 patients (22.9%) had PAD. The PAD group had a higher prevalence of diabetes mellitus ( = 0.026), elevated serum C-reactive protein (CRP) levels ( < 0.001) and increased PCS levels ( = 0.002) than the normal ABI group. Multivariate logistic regression showed that PCS (odds ratio [OR]: 1.154, 95% confidence interval [CI]: 1.013-1.315, = 0.031) and CRP (per 0.1 mg/dL increase, OR: 1.649, 95% CI: 1.138-2.389, = 0.008) were independently associated with PAD. According to Spearman's correlation analysis, log-transformed PCS (log-PCS) levels negatively correlated with left or right ABI ( = 0.001 and = 0.004, respectively) and estimated glomerular filtration rate ( = 0.001) but positively correlated with log-CRP ( = 0.024). : Elevated serum PCS and CRP levels are significantly associated with PAD in patients with hypertension, suggesting the potential role of PCS in PAD pathogenesis.
对甲酚硫酸酯（PCS）与炎症、氧化应激和血管功能障碍有关。高血压是外周动脉疾病（PAD）的主要危险因素，而外周动脉疾病与高血压患者死亡率增加有关。本研究旨在评估高血压患者血清PCS水平与PAD之间的关联。我们分析了心血管门诊105例高血压患者的空腹血样和临床数据。采用高效液相色谱-质谱法定量血清PCS水平。使用自动示波装置测量踝臂指数（ABI）；ABI<0.9表明患有PAD。共有24例患者（22.9%）患有PAD。与正常ABI组相比，PAD组糖尿病患病率更高（P=0.026），血清C反应蛋白（CRP）水平升高（P<0.001），PCS水平升高（P=0.002）。多因素逻辑回归显示，PCS（比值比[OR]：1.154，95%置信区间[CI]：1.013 - 1.315，P=0.031）和CRP（每增加0.1mg/dL，OR：1.649，95%CI：1.138 - 2.389，P=0.008）与PAD独立相关。根据Spearman相关性分析，对数转换后的PCS（log-PCS）水平与左或右ABI呈负相关（分别为P=0.001和P=0.004），与估计肾小球滤过率呈负相关（P=0.001），但与log-CRP呈正相关（P=0.024）。血清PCS和CRP水平升高与高血压患者的PAD显著相关，提示PCS在PAD发病机制中的潜在作用。
