Rothwell N J, Stock M J
Department of Physiology, St George's Hospital Medical School, London, UK.
Int J Obes. 1987;11(6):641-7.
Daily injection of lean Zucker rats with a beta 2-adrenergic agonist (clenbuterol, 1 mg/kg) for 22 day increased weight gained by 38 per cent; there were significant increases in carcass protein and water, but fat content was unaltered. Clenbuterol did not affect energy intake or expenditure, the acute thermogenic response to food, or brown adipose tissue (BAT) activity (assessed from mitochondrial purine nucleotide (GDP) binding). In obese Zucker rats, clenbuterol significantly depressed energetic efficiency and increased the thermogenic response to food and BAT activity in these mutants. Body weight gain was not significantly affected by clenbuterol in obese Zucker rats but this was because of a 19 per cent reduction in fat content accompanied by a simultaneous 13 per cent increase in protein content. The ratio of protein/fat gained during the study was increased by 50 and 173 per cent by clenbuterol in lean and obese rats, respectively. Thus, clenbuterol exhibits potent anabolic effects on lean body mass in genetically obese as well as lean rats, but also increases thermogenesis and reduces body fat content in the obese mutants.
每天给瘦型 Zucker 大鼠注射β2 肾上腺素能激动剂（克伦特罗，1 毫克/千克），持续 22 天，体重增加了 38%；胴体蛋白质和水分显著增加，但脂肪含量未改变。克伦特罗不影响能量摄入或消耗、对食物的急性产热反应或棕色脂肪组织（BAT）活性（通过线粒体嘌呤核苷酸（GDP）结合评估）。在肥胖 Zucker 大鼠中，克伦特罗显著降低了能量效率，并增加了这些突变体对食物的产热反应和 BAT 活性。克伦特罗对肥胖 Zucker 大鼠的体重增加没有显著影响，但这是因为脂肪含量降低了 19%，同时蛋白质含量增加了 13%。在研究期间，克伦特罗使瘦型和肥胖大鼠获得的蛋白质/脂肪比率分别增加了 50%和 173%。因此，克伦特罗对遗传性肥胖大鼠和瘦型大鼠的瘦体重均表现出强大的合成代谢作用，但也增加了肥胖突变体的产热并降低了体脂含量。
