Brandt K R, Mackenzie T B
Department of Psychiatry, University of Minnesota Medical School.
Int J Psychiatry Med. 1987;17(4):361-6. doi: 10.2190/ybuc-bve7-jgel-j5w3.
An established obsessive compulsive disorder (OCD) in a twenty-six-year-old woman, characterized by obsessional fear of rat germs and ritualistic cleansing, was observed to worsen during pregnancy. The patient's OCD had followed a fluctuating course for three years but she had not previously experienced a decompensation of such duration and severity. During her pregnancy she became depressed and suicidal, was unable to care for her family and spent the majority of her confinement in the hospital. Several mechanisms are discussed which might explain the exacerbation.
一名26岁患有强迫症（OCD）的女性，其特征为对老鼠病菌的强迫性恐惧和仪式性清洁行为，在孕期病情加重。该患者的强迫症已呈波动病程三年，但此前未曾经历过如此长时间和严重程度的失代偿。孕期她变得抑郁并有自杀倾向，无法照顾家人，大部分产褥期都在医院度过。文中讨论了几种可能解释病情加重的机制。
