Clinical Laboratory, DongYang People's Hospital, Dongyang, Zhejiang, China.
PLoS One. 2021 Aug 18;16(8):e0255744. doi: 10.1371/journal.pone.0255744. eCollection 2021.
Previous studies have shown that lactate/albumin ratio (LAR) can be used as a prognostic biomarker to independently predict the mortality of sepsis and severe heart failure. However, the role of LAR as an independent prognostic factor in all-cause mortality in patients with acute respiratory failure (ARF) remains to be clarified. Therefore, we retrospectively analyzed 2170 patients with ARF in Medical Information Mart for Intensive Care Database III from 2001 to 2012. By drawing the receiver operating characteristic curve, LAR shows a better predictive value in predicting the 30-day mortality of ARF patients (AUC: 0.646), which is higher than that of albumin (AUC: 0.631) or lactate (AUC: 0.616) alone, and even higher than SOFA score(AUC: 0.642). COX regression analysis and Kaplan-Meier curve objectively and intuitively show that high LAR is a risk factor for patients with ARF, which is positively correlated with all-cause mortality. As an easy-to-obtain and objective biomarker, LAR deserves further verification by multi-center prospective studies.
先前的研究表明，乳酸/白蛋白比值（LAR）可用作预测生物标志物，独立预测脓毒症和严重心力衰竭患者的死亡率。然而，LAR 作为急性呼吸衰竭（ARF）患者全因死亡率的独立预后因素的作用仍需阐明。因此，我们回顾性分析了 2001 年至 2012 年医疗信息集市重症监护数据库 III 中 2170 例 ARF 患者。通过绘制受试者工作特征曲线，LAR 显示出在预测 ARF 患者 30 天死亡率方面具有更好的预测价值（AUC：0.646），优于单独的白蛋白（AUC：0.631）或乳酸（AUC：0.616），甚至高于 SOFA 评分（AUC：0.642）。COX 回归分析和 Kaplan-Meier 曲线客观而直观地表明，高 LAR 是 ARF 患者的一个危险因素，与全因死亡率呈正相关。作为一种易于获取和客观的生物标志物，LAR 值得通过多中心前瞻性研究进一步验证。
