Díez Marques M L, Lucio Cazaña F J, Rodringuez Puyol M
Physiology and Pharmacology Department, Alcalá de Henares University, Spain.
Int J Vitam Nutr Res. 1987;57(4):375-9.
Rats receiving daily IP injections of dl-alpha-tocopheryl acetate (50 mg/kg) for 4 days showed levels of plasma alpha-tocopherol slightly increased and normal platelet count but platelet aggregation (induced by ADP or adrenaline) was significantly decreased when compared with the control animals. In addition, both platelet-rich plasma and platelet-poor plasma-thromboelastograms from treated rats showed thromboplastine-formation times significantly higher than those from control animals. Serum biochemical parameters showed several minor modifications in treated rats with respect the control ones. It suggests that vitamin E could be considered as a possible useful tool for the therapy of several hyperaggregable or hypercoagulable states.
连续4天每日腹腔注射dl-α-生育酚醋酸酯（50毫克/千克）的大鼠，其血浆α-生育酚水平略有升高，血小板计数正常，但与对照动物相比，（由二磷酸腺苷或肾上腺素诱导的）血小板聚集显著降低。此外，处理组大鼠的富血小板血浆和贫血小板血浆血栓弹力图显示，凝血活酶形成时间显著高于对照动物。血清生化参数显示，处理组大鼠与对照组相比有一些微小变化。这表明维生素E可被视为治疗几种血小板高聚集或高凝状态的一种可能有用的工具。
