Diabetes Research Group, Medizinische Klinik und Poliklinik IV, LMU Klinikum, München, Germany.
Clinical Cooperation Group Type 2 Diabetes, Helmholtz Zentrum München, Neuherberg, Germany.
Exp Clin Endocrinol Diabetes. 2022 Jun;130(6):393-399. doi: 10.1055/a-1500-4605. Epub 2021 Aug 18.
The myokine myostatin regulates muscle mass and has been linked to insulin resistance and metabolic syndrome. However, data on its role in humans is still limited. We, therefore, investigated the associations of serum myostatin with muscle mass, physical fitness, and components of the metabolic syndrome in a cohort of premenopausal women.
We undertook a cross-sectional analysis of 233 women from the monocenter study PPSDiab, conducted in Munich, Germany. Participants had recently completed a pregnancy with or without gestational diabetes. Our analysis included medical history, anthropometrics, oral glucose tolerance testing, laboratory chemistry, cardiopulmonary exercise testing, and magnetic resonance imaging (n=142) of visceral fat volume, left quadriceps muscle mass, and muscle fat content. Serum myostatin was quantified by a competitive enzyme-linked immunosorbent assay.
We observed positive correlations of serum myostatin with body mass index (ρ=0.235; p=0.0003), body fat percentage (ρ=0.166; p=0.011), waist circumference (ρ=0.206; p=0.002), intraabdominal fat volume (ρ=0.182; p=0.030) and high-sensitivity C-reactive protein (ρ=0.175; p=0.008). These correlations were reproduced in linear regression analyses with adjustment for age and time after delivery. We saw no correlations with muscle mass, physical fitness, insulin sensitivity, triglycerides, HDL cholesterol, and blood pressure.
Our observation of elevated serum myostatin in women with a higher body fat percentage, visceral obesity, and elevated c-reactive protein suggests that this myokine contributes to the altered muscle-adipose tissue crosstalk in metabolic syndrome. Elevated myostatin may advance this pathophysiologic process and could also impair the efficacy of exercise interventions. Further mechanistic studies, therefore, seem warranted.
肌肉调节素(myostatin)调节肌肉质量，与胰岛素抵抗和代谢综合征有关。然而，其在人类中的作用数据仍然有限。因此，我们在一组绝经前妇女中研究了血清肌肉调节素与肌肉质量、身体适应性和代谢综合征成分的关系。
我们对德国慕尼黑单中心 PPSDiab 研究中的 233 名女性进行了横断面分析。参与者最近完成了一次妊娠，无论是否患有妊娠期糖尿病。我们的分析包括病史、人体测量学、口服葡萄糖耐量试验、实验室化学、心肺运动试验和磁共振成像（n=142），用于测量内脏脂肪量、左股四头肌肌肉量和肌肉脂肪含量。血清肌肉调节素通过竞争性酶联免疫吸附测定法进行定量。
我们观察到血清肌肉调节素与体重指数（ρ=0.235；p=0.0003）、体脂肪百分比（ρ=0.166；p=0.011）、腰围（ρ=0.206；p=0.002）、腹内脂肪量（ρ=0.182；p=0.030）和高敏 C 反应蛋白（ρ=0.175；p=0.008）呈正相关。这些相关性在调整年龄和分娩后时间的线性回归分析中得到了重现。我们没有观察到与肌肉质量、身体适应性、胰岛素敏感性、甘油三酯、高密度脂蛋白胆固醇和血压的相关性。
我们观察到脂肪百分比较高、内脏肥胖和 C 反应蛋白升高的女性血清肌肉调节素升高，这表明这种肌肉调节素有助于代谢综合征中改变的肌肉-脂肪组织相互作用。升高的肌肉调节素可能会促进这一病理生理过程，也可能会损害运动干预的效果。因此，似乎需要进一步的机制研究。
