Hu J Y, Liao Y, Huang C H, Wang S, Liu Z G
Department of Ophthalmology, Xiang'an Hospital and Xiamen Eye Center Affiliated to Xiamen University, Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Fujian Engineering and Research Center of Eye Regenerative Medicine, Xiamen 361102, China.
Zhonghua Yi Xue Za Zhi. 2021 Aug 24;101(32):2514-2518. doi: 10.3760/cma.j.cn112137-20210223-00466.
To evaluate the association of meibomian gland dysfunction (MGD) and body mass index (BMI) in Chinese adults. A total of 2 419 patients were retrospectively recruited between May and October 2013 from 33 ocular surface disease clinic in China. There were 780 males (32.2%) and 1 639 females (67.8%), aged 18-89 (46±16) years. BMI value of each patient was respectively calculated, and the patients were divided into underweight, normal weight, overweight and obesity groups accordingly. Meibomian gland-related examinations were performed in right eyes. The number of the patients in four groups were 196, 1 556, 567 and 100, respectively. Compared with normal weight group, the rates of moderate to severe MGD (59.1%, 71.0% vs 49.9%) in overweight group and obesity group were higher, and the differences were statistically significant (both <0.05). The scores of change in eyelid margin, meibomian gland dropout and meibum expressibility were significantly higher in overweight group and obesity group, compared with normal weight group (all <0.05). Additionally, after stratified by age, all the above-mentioned three scores of obese patients were significantly higher than those of non-obese patients in young adult group. Multivariate logistic regression analysis showed that moderate to severe MGD was correlated with overweight (=2.19, 95%: 1.06-4.50, =0.033) and obesity (=3.70, 95%: 2.57-5.04, =0.008). Moderate to severe MGD significantly correlates with high BMI in Chinese adults.
评估中国成年人睑板腺功能障碍（MGD）与体重指数（BMI）之间的关联。2013年5月至10月，从中国33个眼表疾病诊所回顾性招募了2419例患者。其中男性780例（32.2%），女性1639例（67.8%），年龄18 - 89岁（46±16岁）。分别计算每位患者的BMI值，并据此将患者分为体重过轻、正常体重、超重和肥胖组。对右眼进行睑板腺相关检查。四组患者人数分别为196例、1556例、567例和100例。与正常体重组相比，超重组和肥胖组中重度MGD的发生率更高（分别为59.1%、71.0%对49.9%），差异具有统计学意义（均<0.05）。与正常体重组相比，超重组和肥胖组睑缘变化、睑板腺缺失和睑脂排出能力的评分显著更高（均<0.05）。此外，按年龄分层后，在年轻成年组中，肥胖患者的上述三项评分均显著高于非肥胖患者。多因素logistic回归分析显示，中重度MGD与超重（β=2.19，95%CI：1.06 - 4.50，P=0.033）和肥胖（β=3.70，95%CI：2.57 - 5.04，P=0.008）相关。中国成年人中重度MGD与高BMI显著相关。
