Shi Yi-Dan, Shu Hui-Ye, Liu Li-Qi, Li Shi-Qi, Liao Xu-Lin, Pan Yi-Cong, Su Ting, Zhang Li-Juan, Kang Min, Ying Ping, Shao Yi
Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong 999077, China.
Brain Sci. 2022 Aug 15;12(8):1078. doi: 10.3390/brainsci12081078.
To investigate the altered functional connectivity (FC) of the cerebral hemispheres in patients with morbid obesity (MO) with meibomian gland dysfunction (MGD) by voxel-mirrored homotopic connectivity (VMHC).
Patients and matched healthy controls (HCs) were recruited, and all subjects underwent functional resonance magnetic imaging (fMRI), and VMHC results were processed statistically to assess the differences in FC in different brain regions between the two groups. We further used ROC curves to evaluate the diagnostic value of these differences. We also used Pearson's correlation analysis to explore the relationship between changes in VMHC values in specific brain regions, visual acuity, and Mini-Mental State Examination (MMSE) score.
Patients with morbid obesity and MGD had abnormal FC in the cerebral hemispheres in several specific brain areas, which were mainly concentrated in pathways related to vision and perception and may correlate to some extent with the clinical presentations of the patients.
通过体素镜像同伦连接（VMHC）研究患有睑板腺功能障碍（MGD）的病态肥胖（MO）患者大脑半球功能连接（FC）的改变。
招募患者和匹配的健康对照（HCs），所有受试者均接受功能磁共振成像（fMRI），并对VMHC结果进行统计学处理，以评估两组不同脑区FC的差异。我们进一步使用ROC曲线评估这些差异的诊断价值。我们还使用Pearson相关性分析来探索特定脑区VMHC值变化、视力和简易精神状态检查表（MMSE）评分之间的关系。
患有病态肥胖和MGD的患者在几个特定脑区的大脑半球存在异常FC，主要集中在与视觉和感知相关的通路，并且可能在一定程度上与患者的临床表现相关。
