Department of Surgery, UC San Diego, San Diego, CA, USA.
Department of Surgery, UC San Diego, San Diego, CA, USA; Department of Surgical Oncology, Dana Farber Cancer Center, Boston, MA, USA.
Am J Surg. 2022 Apr;223(4):686-693. doi: 10.1016/j.amjsurg.2021.07.027. Epub 2021 Jul 26.
Fluorescence angiography (FA) using indocyanine green dye (ICG) has recently been introduced for real-time identification of parathyroid adenomas. However, time to peak fluorescence has not yet been critically evaluated.
This was a retrospective review of parathyroidectomies with ICG FA over a one-year period.
There were 66 patients with average age of 64 years. The average time to initial fluorescence was 26.7 s and to peak fluorescence was 38.0 s. The time to saline flush administration significantly correlated with times to initial and peak fluorescence (p < .0001). The rate of in-situ fluorescence was 97%. The rates of suspected adenoma detection were 69% for sestamibi scan, 71% for ultrasound, and 96% for CT scan. Imaging was discordant in 13 cases (20%), with the adenoma located on the opposite side of the neck in 4 cases.
ICG FA is a rapid and effective adjunct for the intraoperative identification of parathyroid adenomas.
荧光血管造影术（FA）使用吲哚菁绿染料（ICG）最近被引入用于实时识别甲状旁腺腺瘤。然而，荧光峰值时间尚未得到严格评估。
这是一项为期一年的使用 ICG FA 的甲状旁腺切除术的回顾性研究。
共有 66 例患者，平均年龄为 64 岁。初始荧光的平均时间为 26.7 秒，达到峰值荧光的时间为 38.0 秒。生理盐水冲洗给药的时间与初始和峰值荧光的时间显著相关（p < 0.0001）。原位荧光率为 97%。可疑腺瘤检测的检出率为 sestamibi 扫描 69%、超声 71%、CT 扫描 96%。13 例（20%）影像学结果不一致，其中 4 例腺瘤位于颈部对侧。
ICG FA 是术中识别甲状旁腺腺瘤的快速有效的辅助手段。
