Katz K, Cohen I J, Ziv N, Grunebaum M, Zaizov R, Yosipovitch Z
Department of Orthopedic Surgery, Beilinson Medical Center, Petah Tiqva, Israel.
J Bone Joint Surg Am. 1987 Dec;69(9):1361-70.
A series of twenty-three pathological fractures in nine children who had Gaucher disease was reviewed. Infiltration of the medullary space by Gaucher cells, erosion of bone, osteonecrosis in the area of the fracture, and disuse osteoporosis were the main etiological factors. Bone scans indicated that the osteonecrosis was due to osseous ischemia that occurred two to twelve months before the pathological fracture. Fracture-healing was prolonged, taking as long as two years for completion in some patients. Inadequate periods of immobilization and early weight-bearing led to malunion.
对9名患有戈谢病的儿童发生的23例病理性骨折进行了回顾性研究。戈谢细胞浸润骨髓腔、骨质侵蚀、骨折部位的骨坏死以及废用性骨质疏松是主要病因。骨扫描显示，骨坏死是由于病理性骨折前两到十二个月发生的骨缺血所致。骨折愈合时间延长，一些患者长达两年才完成愈合。固定时间不足和过早负重导致了骨折畸形愈合。
