母亲精神健康障碍对死产和婴儿死亡率风险的作用：系统评价和荟萃分析方案。

Role of maternal mental health disorders on stillbirth and infant mortality risk: a protocol for a systematic review and meta-analysis.

机构信息

Telethon Kids Institute, The University of Western Australia, Nedlands, Western Australia, Australia

Telethon Kids Institute, The University of Western Australia, Nedlands, Western Australia, Australia.

出版信息

BMJ Open. 2020 May 5;10(5):e036280. doi: 10.1136/bmjopen-2019-036280.

DOI:10.1136/bmjopen-2019-036280

PMID:32371521

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7228523/

Abstract

INTRODUCTION

Maternal mental health disorders such as anxiety and depression are major public health concerns. Evidence shows a link between maternal mental health disorders and preterm birth and low birth weight. However, the impacts of maternal mental health disorders on stillbirth and infant mortality have been less investigated and inconsistent findings have been reported. Thus, using the available literature, we plan to examine whether prenatal maternal mental health disorders impact the risk of stillbirth and infant mortality.

METHODS AND ANALYSIS

This systematic review and meta-analysis will adhere to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and will be registered with the International Prospective Register of Systematic Reviews. Systematic searches will be conducted (from database inception to December 2019) in Medline, Embase, PsycINFO and Scopus for studies examining the association of prenatal mental health disorders and stillbirth and infant mortality. The search will be limited to studies published in English language and in humans only, with no restriction on the year of publication. Two independent reviewers will evaluate records and assess the quality of individual studies. The Newcastle-Ottawa scales and GRADE (Grading of Recommendations, Assessment, Development and Evaluations) approach will be used to assess the methodological quality and bias of the included studies. In addition to a narrative synthesis, a random-effects meta-analysis will be conducted when sufficient data are available. I statistics will be used to assess between-study heterogeneity in the estimated effect size.

ETHICS AND DISSEMINATION

As it will be a systematic review and meta-analysis based on previously published evidence, there will be no requirement for ethical approval. Findings will be published in a peer-reviewed journal and will be presented at various conferences.

PROSPERO REGISTRATION NUMBER

摘要

简介

孕产妇的精神健康障碍，如焦虑和抑郁，是一个主要的公共卫生关注点。有证据表明，孕产妇的精神健康障碍与早产和低出生体重之间存在关联。然而，孕产妇精神健康障碍对死产和婴儿死亡率的影响研究较少，且已有研究结果并不一致。因此，我们计划利用现有文献，来研究产前孕产妇精神健康障碍是否会增加死产和婴儿死亡率的风险。

方法和分析

本系统评价和荟萃分析将遵循系统评价和荟萃分析的首选报告项目，并将在国际前瞻性系统评价登记处进行注册。从数据库建立到 2019 年 12 月，我们将在 Medline、Embase、PsycINFO 和 Scopus 中进行系统搜索，以寻找研究产前精神健康障碍与死产和婴儿死亡率之间关联的文献。检索将仅限于以英文发表、仅针对人类的研究，对发表年份不设限制。两名独立的审查员将评估记录并评估单个研究的质量。将使用纽卡斯尔-渥太华量表和 GRADE（推荐评估、制定与评价分级）方法来评估纳入研究的方法学质量和偏倚。除了进行叙述性综合分析外，如果有足够的数据，还将进行随机效应荟萃分析。将使用 I ²统计量来评估估计效应量的研究间异质性。