Meghee S, Mooney C, Deshmukh A A, O'Neill C J, Bowes S, Royston J P, Dobbs S M, Dobbs R J
School of Pharmacy, London, U.K.
J Clin Pharm Ther. 1987 Dec;12(6):415-8. doi: 10.1111/j.1365-2710.1987.tb00555.x.
In subjects capable of normal everyday activity, exercise has been shown to lower the serum digoxin concentration by increasing uptake into skeletal muscle. A randomized cross-over study of the effect on the serum digoxin concentration of treatments consisting of rest for, or exercise during, 30 min was carried out in 20 elderly patients undergoing rehabilitation. In one patient exercise was associated with a marked (40%) reduction in the serum digoxin concentration. In the remainder there was a very small, but statistically significant, fall in concentration in the exercise as compared with the rest period. Unexpectedly low serum digoxin concentrations in in-patients of geriatric units, may occasionally be an artefact due to temporary redistribution of digoxin.
在能够进行正常日常活动的受试者中，运动已被证明可通过增加骨骼肌摄取来降低血清地高辛浓度。对20名正在接受康复治疗的老年患者进行了一项随机交叉研究，该研究观察了30分钟休息或运动治疗对血清地高辛浓度的影响。在一名患者中，运动使血清地高辛浓度显著降低（40%）。在其余患者中，与休息期相比，运动期血清地高辛浓度有非常小但具有统计学意义的下降。老年病房住院患者血清地高辛浓度意外降低，偶尔可能是由于地高辛暂时重新分布造成的假象。
