心房颤动患者在不同血清地高辛浓度下的运动心率。
Exercise heart rates at different serum digoxin concentrations in patients with atrial fibrillation.
作者信息
Beasley R, Smith D A, McHaffie D J
出版信息
Br Med J (Clin Res Ed). 1985 Jan 5;290(6461):9-11. doi: 10.1136/bmj.290.6461.9.
Abstract
Heart rate at rest and during increasing workloads was measured in a double blind study of 12 patients with chronic atrial fibrillation when serum concentrations of digoxin were nil and at low and high therapeutic values. Twelve normal subjects were studied for comparison. The heart rate at all levels of exercise in most patients with atrial fibrillation was not adequately controlled by any serum digoxin concentration tested despite a reduction in heart rate with increasing serum digoxin concentrations. Control of the resting heart rate, even in patients with high serum digoxin concentrations, did not ensure adequate control of the heart rate during work rates equivalent to regular daily activities.
摘要
在一项双盲研究中，对12例慢性心房颤动患者在血清地高辛浓度为零、低治疗值和高治疗值时静息及负荷增加时的心率进行了测量。选取12名正常受试者作为对照。尽管随着血清地高辛浓度升高心率有所降低，但大多数心房颤动患者在任何测试的血清地高辛浓度下，其在所有运动水平时的心率均未得到充分控制。即使是血清地高辛浓度较高的患者，静息心率得到控制也不能确保在相当于日常常规活动的工作强度下心率得到充分控制。
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