Kohli Pavneet, Penumadu Prasanth, Srivastava Neelesh, Srinivas Bheemanathi Hanuman, Rangarajan Vidyalakshmi
Department of Surgical Oncology, JIPMER, Puducherry, 6050006 India.
Department of Pathology, JIPMER, Puducherry, 605006 India.
J Obstet Gynaecol India. 2021 Jun;71(3):326-329. doi: 10.1007/s13224-021-01437-6. Epub 2021 Feb 6.
Endometrial stromal sarcoma is an uncommon gynecological tumor. Extra-uterine endometrial stromal sarcoma (EESS), the extra-uterine variant of its relatively more common counterpart, is even rarer with only few documented case reports. We report a case of a 40-year woman with bilateral adnexal tumors and synchronous invasive ductal breast carcinoma (IDC) posing a diagnostic challenge. The histopathology of specimen confirmed the diagnosis of EESS in the absence of florid endometriosis and synchronous hormone-positive infiltrating duct cancer in the breast. Patient was started on adjuvant endocrine therapy and is disease free at the end of 2 years. To the best of our knowledge, this is the first documentation of synchronous presentation of IDC and EESS, highlighting the possible role of hyper-estrogenemia as an etiological factor.
子宫内膜间质肉瘤是一种罕见的妇科肿瘤。子宫外子宫内膜间质肉瘤（EESS）是其相对更常见的子宫内对应肿瘤的子宫外变体，更为罕见，仅有少数病例报告。我们报告一例40岁女性，患有双侧附件肿瘤和同步浸润性导管乳腺癌（IDC），这给诊断带来了挑战。标本的组织病理学证实诊断为EESS，且不存在明显的子宫内膜异位症，同时乳房中存在激素阳性浸润性导管癌。患者开始接受辅助内分泌治疗，2年后无疾病。据我们所知，这是首次记录到IDC和EESS的同步表现，突出了高雌激素血症作为病因的可能作用。
