Pathology, Immunology and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA.
Pathology, Immunology and Laboratory Medicine, Rutgers New Jersey Medical School, Newark, NJ, USA.
Ann Diagn Pathol. 2022 Aug;59:151966. doi: 10.1016/j.anndiagpath.2022.151966. Epub 2022 May 10.
Endometrial stromal sarcoma (ESS) is the second most common uterine mesenchymal neoplasm. ESS can arise from extrauterine locations without any uterine involvement and is called extrauterine ESS (EESS). The epidemiological features of EESS are not well-known. Moreover, the factors affecting its outcome have not been systemically studied. The treatment of EESS closely follows that of uterine ESS, comprised of different combinations of surgical management, hormone therapy, chemotherapy, and radiation therapy. However, the effectiveness of different treatment protocols for EESS has not been studied. Here, we have performed a systematic review of all reported cases of EESS in the English literature. We further performed a meta-analysis of the outcome data and investigated how the patients' age, tumor site, tumor size, and management affect the overall and progression-free survival of the patients. We found that tumor site and mode of treatment significantly affected the overall survival and progression-free survival of the patients. Tumor size significantly affected overall survival but not progression-free survival, while the age at diagnosis did not affect patient outcome. As far as we know, ours is the first systematic study of this rare malignancy with an emphasis on outcome analysis.
子宫内膜间质肉瘤（ESS）是第二常见的子宫间叶性肿瘤。ESS 可发生于无子宫参与的子宫外部位，称为子宫外 ESS（EESS）。EESS 的流行病学特征尚不清楚。此外，影响其预后的因素尚未系统研究。ESS 的治疗与子宫 ESS 密切相关，包括手术管理、激素治疗、化疗和放疗的不同组合。然而，对于 EESS 的不同治疗方案的有效性尚未进行研究。在这里，我们对英文文献中所有报道的 EESS 病例进行了系统回顾。我们进一步对结局数据进行了荟萃分析，并研究了患者的年龄、肿瘤部位、肿瘤大小和治疗方式如何影响患者的总生存率和无进展生存率。我们发现肿瘤部位和治疗方式显著影响患者的总生存率和无进展生存率。肿瘤大小显著影响总生存率，但不影响无进展生存率，而诊断时的年龄不影响患者的预后。据我们所知，这是第一项对这种罕见恶性肿瘤进行的系统研究，重点是对结局进行分析。
