Marek-Józefowicz Luiza, Jaracz Marcin, Borkowska Alina
Department of Dermatology and Venerology, Faculty of Medicine, Ludwik Rydygier Medical College in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
Chair of Clinical Neuropsychology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
Postepy Dermatol Alergol. 2021 Feb;38(2):137-143. doi: 10.5114/ada.2021.104289. Epub 2021 Mar 10.
Psoriasis is a chronic inflammatory skin disease, in which psychological factors play an important role. In the studies of common markers of psoriasis and depression, the abnormal function of the stress axis in both diseases is highlighted, whereas interleukin-6 (IL-6) and interleukin-1 are indicated as particularly important.
To evaluate the relationship between the affective temperament traits and the intensity of depressive symptoms in patients with psoriasis in the context of immunoenzymatic markers.
The study included 208 subjects. Severity of psoriasis was assessed by PASI. TEMPS-A was applied for the evaluation of affective temperament and BDI was used for the assessment of the intensity of depressive symptoms. The level of cytokines was determined by means of the immunoenzymatic method.
Patients presented a specific profile of affective temperament, with higher scores on depressive, anxious and irritable dimensions. The severity of depressive symptoms correlated positively with the severity of psoriasis. A significant correlation was found between IL-6 and the severity of psoriasis in patients with depressive disorders and psoriasis. No similar correlation was found in patients without depressive disorder.
Results of the present study show common mechanisms for psoriasis and depression. Specific traits of affective temperament may play an important role in the clinical picture of both diseases. Higher levels of IL-6 in patients with psoriasis predispose to more frequent occurrence of depressive disorders and the depressive dimension of affective temperament.
银屑病是一种慢性炎症性皮肤病，心理因素在其中起着重要作用。在银屑病和抑郁症常见标志物的研究中，两种疾病应激轴的功能异常受到关注，而白细胞介素-6（IL-6）和白细胞介素-1被认为尤为重要。
在免疫酶标志物的背景下，评估银屑病患者情感气质特征与抑郁症状强度之间的关系。
该研究纳入208名受试者。通过银屑病面积和严重程度指数（PASI）评估银屑病的严重程度。应用情感气质评估量表（TEMPS-A）评估情感气质，使用贝克抑郁量表（BDI）评估抑郁症状的强度。采用免疫酶法测定细胞因子水平。
患者呈现出特定的情感气质特征，在抑郁、焦虑和易怒维度上得分较高。抑郁症状的严重程度与银屑病的严重程度呈正相关。在患有抑郁症和银屑病的患者中，发现IL-6与银屑病严重程度之间存在显著相关性。在无抑郁症的患者中未发现类似相关性。
本研究结果显示了银屑病和抑郁症的共同机制。情感气质的特定特征可能在两种疾病的临床表现中起重要作用。银屑病患者中较高水平的IL-6易导致更频繁地出现抑郁症和情感气质的抑郁维度。
