Mullen G B, Swift P A, Georgiev V S
Department of Organic Chemistry, Pennwalt Corporation, Rochester, NY 14623.
J Pharm Sci. 1987 Dec;76(12):930-4. doi: 10.1002/jps.2600761218.
The preparation and potential anti-inflammatory activity of a series of novel substituted spiro[isoxazolidine-3,2'-tricyclo[3.3.1.1(3,7)]decanes] (7, 11-30) are reported. The synthesis of the title compounds was accomplished via a 1,3-dipolar cycloaddition reaction of nitrones with appropriate olefins.
