ShengYang Lian Bertrand, Lee Krishnamoorthy Thinesh, Oh Choon Chiat
Department of Dermatology, Singapore General Hospital, Singapore.
Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore.
JAAD Int. 2021 Jul 31;4:70-78. doi: 10.1016/j.jdin.2021.06.002. eCollection 2021 Sep.
Liver transplant recipients are at lifelong risk of immunosuppression-related cutaneous complications, such as malignancy and infection.
Our study aims to assess the epidemiology of dermatologic conditions among liver transplant recipients in an academic medical center in Singapore.
Medical records of liver transplant recipients on follow-up with gastroenterology and dermatology departments at the Singapore General Hospital between 2006 and 2021 were retrospectively reviewed. A literature review was subsequently performed on the keywords "liver transplant" and "dermatology."
A total of 99 liver transplant recipients were identified in this study. Sixty-nine patients (70%) had at least 1 dermatologic condition. Inflammatory skin conditions were the most common (53%), followed by cutaneous infection (36%) and benign cutaneous tumors (30%). Malignant and premalignant lesions were the least common skin conditions reported (10%). Our study results concurred with many other studies reported worldwide, demonstrating a low cutaneous malignancy burden after liver transplantation.
The study included a small population size in a single center and did not have a pre-existing protocol for pretransplant dermatologic surveillance.
Although the incidence of skin cancer after liver transplant in Singapore is low, the patients will benefit from long-term dermatology surveillance, given the long-term risks of infection and malignant skin conditions.
肝移植受者终生面临免疫抑制相关皮肤并发症的风险，如恶性肿瘤和感染。
我们的研究旨在评估新加坡一家学术医疗中心肝移植受者皮肤病的流行病学情况。
回顾性分析了2006年至2021年期间在新加坡总医院接受胃肠病学和皮肤科随访的肝移植受者的病历。随后对关键词“肝移植”和“皮肤病学”进行了文献综述。
本研究共纳入99例肝移植受者。69例患者（70%）至少患有一种皮肤病。炎症性皮肤病最为常见（53%），其次是皮肤感染（36%）和良性皮肤肿瘤（30%）。恶性和癌前病变是报告最少见的皮肤疾病（10%）。我们的研究结果与世界范围内其他许多研究一致，表明肝移植后皮肤恶性肿瘤负担较低。
该研究纳入的单中心人群规模较小，且没有预先存在的移植前皮肤病监测方案。
尽管新加坡肝移植后皮肤癌的发病率较低，但鉴于感染和皮肤恶性疾病的长期风险，患者将从长期的皮肤科监测中受益。
