Department of Medicine, National University Hospital, Singapore.
Ann Acad Med Singap. 2010 Dec;39(12):904-5.
There is no published epidemiological data on skin diseases in kidney transplant recipients in this tropical country, which has multi-ethnic groups with the Chinese as the predominant ethnic group.
Skin diseases of 143 renal transplant recipients were studied in a skin clinic of a tertiary institution during annual surveillance visits from June 2006 to March 2009.
Our study showed that except the common drug specific skin manifestations, sebaceous hyperplasia (56.6%), seborrheic keratosis (60.8%), melanocytic naevi (76.9%), skin tags (37.1%) and viral (29.4%) and fungal (20.3%) infections were the most prevalent skin diseases among renal transplant recipients living in Singapore. The prevalence of pre-malignant and malignant tumours was very low (11.2% actinic keratosis, 1.4% Bowen's disease, 1.4% squamous cell carcinoma, 0.7% basal cell carcinoma, 0.7% keratoacanthoma). Male predominance was seen in sebaceous hyperplasia (72.4% vs 32.1%), actinic keratosis (17.2% vs 1.8%), viral (36.8% vs 19.6%) and fungal (27.6% vs 8.9%) infections. Our study also showed increased prevalence of sebaceous hyperplasia with increased age but its prevalence was significantly higher than that reported in the age matched general population. The prevalence of seborrheic keratosis, actinic keratosis and viral infection correlated positively with post-transplant duration.
Our study provides epidemiological data for the prevalence of skin diseases in renal transplant recipients. It emphasises the importance of dermatologic follow-up for renal transplant patients in order to obtain a diagnosis and manage treatable skin diseases.
在这个拥有多民族的热带国家，还没有关于肾移植受者皮肤疾病的发表的流行病学数据，其中以华族为主要族群。
2006 年 6 月至 2009 年 3 月，在一家三级医疗机构的皮肤科诊所，对 143 名肾移植受者进行了皮肤疾病研究。
我们的研究表明，除了常见的药物特异性皮肤表现外，皮脂增生症（56.6%）、脂溢性角化病（60.8%）、黑素细胞痣（76.9%）、皮肤标签（37.1%）以及病毒（29.4%）和真菌感染（20.3%）是新加坡肾移植受者中最常见的皮肤疾病。癌前和恶性肿瘤的患病率非常低（11.2%光化性角化病，1.4% Bowen 病，1.4%鳞状细胞癌，0.7%基底细胞癌，0.7%角化棘皮瘤）。皮脂增生症（72.4%比 32.1%）、光化性角化病（17.2%比 1.8%）、病毒（36.8%比 19.6%）和真菌感染（27.6%比 8.9%）中男性居多。我们的研究还表明，皮脂增生症的患病率随着年龄的增长而增加，但明显高于年龄匹配的一般人群。脂溢性角化病、光化性角化病和病毒感染的患病率与移植后时间呈正相关。
本研究为肾移植受者皮肤疾病的患病率提供了流行病学数据。它强调了对肾移植患者进行皮肤科随访的重要性，以便获得诊断并治疗可治疗的皮肤疾病。
