Division of Dermatology, Internal Medicine Department, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, Brazil.
Pediatr Dermatol. 2021 Sep;38(5):1247-1250. doi: 10.1111/pde.14738. Epub 2021 Aug 18.
Generalized verrucosis is a clinical manifestation of human papillomavirus infection. Patients with generalized verrucosis present with over 20 verrucae distributed over various anatomical sites. The disorder occurs in association with several genetic syndromes with immunodeficiency, including GATA2 deficiency. We report a 12-year-old boy with GATA2 deficiency and generalized verrucosis that worsened after cyclosporine use following bone marrow transplant. Systemic treatment with acitretin and topical application of trichloroacetic acid, likely along with immune reconstitution, led to complete remission.
全身性疣状病是人类乳头瘤病毒感染的一种临床表现。全身性疣状病患者的 20 多个疣分布在不同的解剖部位。这种疾病与几种免疫缺陷相关的遗传综合征有关，包括 GATA2 缺陷。我们报告了一例 12 岁男孩患有 GATA2 缺陷和全身性疣状病，在骨髓移植后使用环孢素后病情恶化。阿维 A 酯全身治疗和三氯乙酸局部应用，可能伴随着免疫重建，导致完全缓解。
