Serrou B, Dubois J B
Dev Biol Stand. 1977;38:369-72.
Female C57 Bl/6 mice (6-8 weeks old) bearing the Lewis or the MBL-2 tumor received a localized irradiation (1,600 Rads; Cobalt 60) three days after the tumor implantation. We compared the association of irradiation and Immuno-BCG-F (1 mg/mice i.v.) with three control groups (no treatment, irradiation alone, Immuno-BCG-F alone). The timing and number of BCG injections varied in the different sub-groups. Results were improved in the Lewis tumor system when BCG was injected just after the end of the irradiation. Efficiency improved with the number of injections (P less than 0.05). In the MBL-2 system, depending on the timing of BCG injections we observed significant survival prolongation (irradiation + BCG) as compared to control groups. It has to be noted that the use of BCG alone enhanced tumor growth in two models.
荷Lewis或MBL - 2肿瘤的雌性C57 Bl/6小鼠（6 - 8周龄）在肿瘤接种后三天接受局部照射（1600拉德；钴60）。我们将照射与免疫卡介苗 - F（1毫克/小鼠静脉注射）联合应用与三个对照组（未治疗、单纯照射、单纯免疫卡介苗 - F）进行比较。卡介苗注射的时间和次数在不同亚组中有所不同。在Lewis肿瘤系统中，当照射结束后立即注射卡介苗时，结果得到改善。随着注射次数增加，疗效提高（P小于0.05）。在MBL - 2系统中，根据卡介苗注射时间的不同，与对照组相比，我们观察到（照射 + 卡介苗）组有显著的生存延长。必须指出的是，在两种模型中单纯使用卡介苗会促进肿瘤生长。
