Dubois J B, Serrou B
Cancer Res. 1976 May;36(5):1731-4.
Three groups of 6 to 8-week-old male mice with transplanted C57BL/6 X DBA/2F1 tumor were irradiated by a single dose of 60Co localized on the tumor in association with i.p. injections of lyophilized Bacillus Calmette-Guérin. When the animals were sacrificed, tumor parameters (weight, surface area, and volume) were determined. Lung metastases were counted using a binocular magnifying glass. When Bacillus Calmette-Guérin injections were begun the day after the irradiation, tumor growth and the number of lung metastases were significantly decreased in comparison with the control group (p less than 0.01). However, there was no significant difference between the control group, which received radiotherapy alone, and the groups in which Bacillus Calmette-Guérin treatment was started after the 4th day postirradiation. This emphasizes the importance of timing in combined radioimmunological treatment.
将三组移植了C57BL/6 X DBA/2F1肿瘤的6至8周龄雄性小鼠，用单次剂量的60Co进行肿瘤局部照射，并腹腔注射冻干卡介苗。处死动物后，测定肿瘤参数（重量、表面积和体积）。用双目放大镜计数肺转移灶。当在照射后第二天开始注射卡介苗时，与对照组相比，肿瘤生长和肺转移灶数量显著减少（p<0.01）。然而，单独接受放射治疗的对照组与照射后第4天开始卡介苗治疗的组之间没有显著差异。这强调了联合放射免疫治疗中时间安排的重要性。
