Mitcheson H D, Castro J E
Dev Biol Stand. 1977;38:509-14.
In a pilot study twelve patients with malignant disease were treated with Corynebacterium parvum. The clinical results were encouraging. A prospective randomised controlled clinical trial of C. parvum therapy in the treatment of patients with carcinoma of the bronchus began in August 1976. 22 pateints have been admitted to the trial and 11 treated with C. parvum. Clinical progress is reported. Radiological, haematological, biochemical and immunological measurements have been made and these results are presented with emphasis on the immunological data. Marked elevation of C. parvum antibody titre occurs. Lymphocyte reactivity, assessed by responses to phytohaemagglutinin and poke-weed mitogen and by the formation of T and B-cell rosettes, was significantly depressed in all patients compared to healthy volunteers, but in patients receiving C. parvum there is a relative increase in B-lymphocyte activity. Mild platelet depression occurs. No alteration to complement activity has been detected.
在一项初步研究中，12名恶性疾病患者接受了短小棒状杆菌治疗。临床结果令人鼓舞。1976年8月开始了一项关于短小棒状杆菌疗法治疗支气管癌患者的前瞻性随机对照临床试验。已有22名患者进入该试验，其中11名接受了短小棒状杆菌治疗。报告了临床进展情况。已进行了放射学、血液学、生物化学和免疫学测量，并重点介绍了免疫学数据。短小棒状杆菌抗体滴度显著升高。与健康志愿者相比，所有患者通过对植物血凝素和商陆有丝分裂原的反应以及T和B细胞玫瑰花结的形成来评估的淋巴细胞反应性明显降低，但接受短小棒状杆菌治疗的患者B淋巴细胞活性相对增加。出现轻度血小板减少。未检测到补体活性的改变。
