Laboratory ImViA EA 7535, Université Bourgogne, Franche-Comté, 21078 Dijon, France
Université Paris-Saclay, CNRS, Institut des Neurosciences Paris-Saclay, 91190 Gif-sur-Yvette, France
Neural Comput. 2021 Jun 11;33(7):1970-1992. doi: 10.1162/neco_a_01399.
Postsynaptic ionotropic receptors critically shape synaptic currents and underpin their activity-dependent plasticity. In recent years, regulation of expression of these receptors by slow inward and outward currents mediated by gliotransmitter release from astrocytes has come under scrutiny as a potentially important mechanism for the regulation of synaptic information transfer. In this study, we consider a model of astrocyte-regulated synapses to investigate this hypothesis at the level of layered networks of interacting neurons and astrocytes. Our simulations hint that gliotransmission sustains the transfer function across layers, although it decorrelates the neuronal activity from the signal pattern. Overall, our results make clear how astrocytes could transform neuronal activity by inducing a lowfrequency modulation of postsynaptic activity.
突触后离子型受体对突触电流起着至关重要的作用，并为其活动依赖性可塑性提供支持。近年来，星形胶质细胞释放神经递质所介导的缓慢内向和外向电流对这些受体表达的调节已成为调节突触信息传递的潜在重要机制，受到了广泛关注。在本研究中，我们考虑了一个星形胶质细胞调节突触的模型，以在相互作用的神经元和星形胶质细胞的分层网络层面上研究这一假说。我们的模拟结果表明，神经递质传递维持了跨层的传递函数，尽管它使神经元活动与信号模式解相关。总的来说，我们的研究结果清楚地表明，星形胶质细胞如何通过诱导突触后活动的低频调制来改变神经元活动。
