Southern Poultry Research Group, Inc., Watkinsville, GA 30677,
Integrated Poultry Health Services, Inc., Watkinsville, GA 30677.
Avian Dis. 2021 Jun;65(2):295-302. doi: 10.1637/aviandiseases-D-20-00126.
Several serotypes of non-host-specific or paratyphoid have been linked with contamination of poultry meat, and eggs, resulting in foodborne outbreaks in humans. Vaccination of poultry against paratyphoid is a frequent strategy used to reduce the levels of infection and transmission, which ultimately can lead to lower rates of human infections. Live vaccines have been developed and used in poultry immediately after hatching as a result of their ability to colonize the gut, stimulate a mucosal immune response, induce a competitive inhibitory effect against homologous wild strains, and reduce colonization and excretion of . Furthermore, vaccines can competitively exclude some heterologous strains of from colonizing the gastrointestinal tract when young poultry are immunologically immature. In addition, various studies have suggested that booster vaccination with live vaccines a few weeks after initial vaccination is essential to increase the level of protection and achieve better cross-protective immunity. Vaccination of breeders, broilers, layers, and turkeys with modified live vaccines is a common intervention that has become an important component in poultry companies' multistep prevention programs to meet increasingly demanding customer and regulatory food safety requirements. Both live and inactivated vaccines play a critical role in a comprehensive control program for chicken and turkey breeders and commercial layers. This review examines the response and protection conferred by live modified vaccines against non-host-specific that can be considered for the design and implementation of vaccination strategies in poultry.
几种非宿主特异性或副伤寒血清型与家禽肉和鸡蛋的污染有关，导致人类食源性疾病爆发。对家禽进行副伤寒疫苗接种是减少感染和传播水平的常用策略，最终可以降低人类感染的发生率。活疫苗由于其在肠道中定植、刺激黏膜免疫反应、对同源野生株产生竞争性抑制作用以及减少定植和排泄的能力，已被开发并用于家禽孵化后立即使用。此外，当幼禽免疫不成熟时，疫苗可以竞争性地排除胃肠道中一些异源的 菌株的定植。此外，各种研究表明，在初始接种后几周内进行活疫苗加强接种对于提高保护水平和实现更好的交叉保护免疫至关重要。用改良的活疫苗对种鸡、肉鸡、蛋鸡和火鸡进行免疫接种是一种常见的干预措施，已成为家禽公司多步骤预防计划的重要组成部分，以满足日益严格的客户和监管食品安全要求。活疫苗和灭活疫苗在鸡和火鸡种鸡和商品蛋鸡的综合控制计划中都发挥着关键作用。这篇综述检查了针对非宿主特异性 的改良活疫苗所引起的反应和保护作用，这可以为家禽疫苗接种策略的设计和实施提供参考。
