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本文引用的文献

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2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis.2021 年美国风湿病学会类风湿关节炎治疗指南。
Arthritis Care Res (Hoboken). 2021 Jul;73(7):924-939. doi: 10.1002/acr.24596. Epub 2021 Jun 8.
2
Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.托珠单抗治疗 COVID-19 住院患者的疗效（RECOVERY）：一项随机、对照、开放标签、平台试验。
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American College of Rheumatology Guidance for COVID-19 Vaccination in Patients With Rheumatic and Musculoskeletal Diseases: Version 1.美国风湿病学会关于风湿性和肌肉骨骼疾病患者接种新冠病毒疫苗的指南：第1版
Arthritis Rheumatol. 2021 Jul;73(7):1093-1107. doi: 10.1002/art.41734. Epub 2021 May 24.
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TNF in the era of immune checkpoint inhibitors: friend or foe?免疫检查点抑制剂时代的肿瘤坏死因子：是友还是敌？
Nat Rev Rheumatol. 2021 Apr;17(4):213-223. doi: 10.1038/s41584-021-00584-4. Epub 2021 Mar 8.
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Immunosuppressive agents for rheumatoid arthritis: a systematic review of clinical trials and their current development stage.类风湿关节炎的免疫抑制剂：临床试验及其当前发展阶段的系统评价
Ther Adv Musculoskelet Dis. 2020 Dec 16;12:1759720X20959971. doi: 10.1177/1759720X20959971. eCollection 2020.
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American College of Rheumatology Guidance for the Management of Rheumatic Disease in Adult Patients During the COVID-19 Pandemic: Version 3.美国风湿病学会在 COVID-19 大流行期间成人患者风湿病管理指南：第 3 版。
Arthritis Rheumatol. 2021 Feb;73(2):e1-e12. doi: 10.1002/art.41596. Epub 2020 Dec 5.
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The global prevalence of rheumatoid arthritis: a meta-analysis based on a systematic review.类风湿关节炎的全球患病率：基于系统综述的荟萃分析。
Rheumatol Int. 2021 May;41(5):863-877. doi: 10.1007/s00296-020-04731-0. Epub 2020 Nov 11.
8
The Challenges of Switching Therapies in an Evolving Multiple Biosimilars Landscape: A Narrative Review of Current Evidence.在不断发展的多种生物类似药领域中切换治疗方案的挑战：当前证据的叙述性综述。
Adv Ther. 2020 Nov;37(11):4491-4518. doi: 10.1007/s12325-020-01472-1. Epub 2020 Sep 10.
9
How do we use biologics in rheumatoid arthritis patients with a history of malignancy? An assessment of treatment patterns using Scandinavian registers.我们如何在有恶性肿瘤病史的类风湿性关节炎患者中使用生物制剂？使用斯堪的纳维亚登记册对治疗模式进行评估。
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10
Drug retention of 7 biologics and tofacitinib in biologics-naïve and biologics-switched patients with rheumatoid arthritis: the ANSWER cohort study.类风湿关节炎患者中生物制剂初治和转换治疗患者中 7 种生物制剂和托法替布的药物保留率：ANSWER 队列研究。
Arthritis Res Ther. 2020 Jun 15;22(1):142. doi: 10.1186/s13075-020-02232-w.

类风湿关节炎的生物疗法：临床医生概述

Biological Therapies for Rheumatoid Arthritis: An Overview for the Clinician.

作者信息

Findeisen Kate E, Sewell Julia, Ostor Andrew J K

机构信息

The Alfred Hospital, Melbourne, Victoria, Australia.

Cabrini Medical Centre, Melbourne, Victoria, Australia.

出版信息

Biologics. 2021 Aug 12;15:343-352. doi: 10.2147/BTT.S252575. eCollection 2021.

DOI:10.2147/BTT.S252575
PMID:34413630
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8370108/
Abstract

Rheumatoid arthritis (RA) is a disease characterised by inflammation of synovial joints and poses a substantial healthcare burden on both the individual and society. One of the most significant shifts in the RA therapeutic landscape has occurred with the introduction of biological disease modifying anti-rheumatic drugs (bDMARDs). There are five classes of bDMARDs currently available, each with a different molecular target and subtle differences in their efficacy and safety profile. This review also describes the "real-world" use of bDMARDs and how they fit into the overall RA treatment guidelines.

摘要

类风湿性关节炎（RA）是一种以滑膜关节炎症为特征的疾病，给个人和社会都带来了沉重的医疗负担。随着生物性疾病改善抗风湿药物（bDMARDs）的引入，RA治疗领域发生了最显著的转变之一。目前有五类bDMARDs可供使用，每类都有不同的分子靶点，其疗效和安全性也存在细微差异。本综述还描述了bDMARDs的“实际应用”以及它们如何融入整体RA治疗指南。