lncRNA FENDRR 在人类癌症中的治疗价值和分子机制。
The Therapeutic Value and Molecular Mechanisms of lncRNA FENDRR in Human Cancer.
机构信息
College of Medical Science, China Three Gorges University, Yichang 443002, China.
College of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002, China.
出版信息
Curr Pharm Des. 2021;27(39):4100-4106. doi: 10.2174/1381612827666210820094702.
BACKGROUND
Long noncoding RNA (lncRNA) fetal-lethal non-coding developmental regulatory RNA (FENDRR), a newly known lncRNA, has been reported to be abnormally expressed in diverse tumors. This review is focused on clarifying the mechanism of FENDRR to regulate the biological process of tumors, affirming its value as a target for tumor therapy.
METHODS
The pathophysiological mechanism of FENDRR acting on tumors has been analyzed and summarized by reviewing PubMed.
RESULTS
The expression of lncRNA FENDRR is abnormally altered in clinical cancers, promoting the malignant transformation of a variety of tumors, including colon cancer, cervical cancer, hepatocellular carcinoma, prostate cancer, Malignant melanoma, lung cancer, osteosarcoma, breast cancer, etc. Cellular processions, including proliferation, invasion, apoptosis and migration affected by FENDRR, have been revealed.
CONCLUSION
Specific evidences for the involvement of LncRNA FENDRR in cancer regulatory processes suggest that FENDRR has the potential to be a biomarker or clinical therapeutic target for malignant tumors.
背景
长非编码 RNA（lncRNA）胎儿致死性非编码发育调控 RNA（FENDRR）是一种新发现的 lncRNA，已在多种肿瘤中报道存在异常表达。本综述重点阐明了 FENDRR 调节肿瘤生物学过程的机制，肯定了其作为肿瘤治疗靶点的价值。
方法
通过检索 PubMed 分析和总结 FENDRR 作用于肿瘤的病理生理机制。
结果
lncRNA FENDRR 在临床癌症中的表达异常改变，促进了多种肿瘤的恶性转化，包括结肠癌、宫颈癌、肝癌、前列腺癌、恶性黑色素瘤、肺癌、骨肉瘤、乳腺癌等。FENDRR 影响的细胞过程，包括增殖、侵袭、凋亡和迁移，已被揭示。
结论
LncRNA FENDRR 参与癌症调控过程的具体证据表明，FENDRR 有可能成为恶性肿瘤的生物标志物或临床治疗靶点。
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