Mammalian & Aquatic Toxicology Department, Central Agricultural Pesticide Laboratory, Agricultural Research Center, 21616-El-Sabahia, Alexandria, Egypt.
Department of Pesticide Chemistry and Technology, Faculty of Agriculture, 21545-El-Shatby, Alexandria University, Alexandria, Egypt.
Environ Toxicol Pharmacol. 2021 Oct;87:103724. doi: 10.1016/j.etap.2021.103724. Epub 2021 Aug 18.
The testicular deficiency associated with exposure to three widely used insecticides in Egyptian agriculture was evaluated. Animals were orally treated with sub-lethal dose (1/50 of the oral LD) of cypermethrin (CYP), imidacloprid (IMC), and chlorpyrifos (CPF) at 5, 9 and 1.9 mg/kg/day, respectively, five times a week for one month. The CYP, IMC, and CPF exposure resulted in a significant decline in animal body weight, sperm count, motility, normality, and viability with increased head and tail deformities. Significant reduction in serum testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH), testis superoxide dismutase (SOD), and reduced glutathione (GSH) levels. In contrast, catalase (CAT), lipid peroxidation (LPO), and protein carbonyl content (PCC) levels were significantly stimulated. Jointly, obtained results were confirmed by microscopic examination of testis sections. The present data concluded that the CYP, IMC, and CPF have a public health impact and violently interferes with male rat reproductive system.
评估了在埃及农业中广泛使用的三种杀虫剂暴露导致的睾丸功能减退。动物经口给予亚致死剂量（口服 LD 的 1/50）的氯菊酯（CYP）、吡虫啉（IMC）和毒死蜱（CPF），分别为 5、9 和 1.9 mg/kg/天，每周 5 次，持续 1 个月。CYP、IMC 和 CPF 的暴露导致动物体重、精子计数、活力、正常性和活力显著下降，头部和尾部畸形增加。血清睾酮、促黄体生成素（LH）、卵泡刺激素（FSH）、睾丸超氧化物歧化酶（SOD）和还原型谷胱甘肽（GSH）水平显著降低。相比之下，过氧化氢酶（CAT）、脂质过氧化（LPO）和蛋白质羰基含量（PCC）水平显著升高。联合获得的结果通过睾丸切片的显微镜检查得到证实。目前的数据得出结论，CYP、IMC 和 CPF 对公共健康有影响，并强烈干扰雄性大鼠的生殖系统。
