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优化黑色素瘤预防和早期检测的短信干预措施:拉丁方交叉 RCT。

Optimizing Texting Interventions for Melanoma Prevention and Early Detection: A Latin Square Crossover RCT.

机构信息

Centre for Health Services Research, Faculty of Medicine, The University of Queensland, Brisbane, Australia.

Cancer Council Queensland, Brisbane, Australia.

出版信息

Am J Prev Med. 2021 Sep;61(3):348-356. doi: 10.1016/j.amepre.2021.03.024. Epub 2021 Jul 21.

DOI:10.1016/j.amepre.2021.03.024
PMID:34419232
Abstract

INTRODUCTION

Text messaging is an effective way to reach large populations with health promotion support. This study aims to establish the optimal text messaging intervention to achieve behavior change in young adults at risk of skin cancer.

STUDY DESIGN

Latin square crossover RCT.

SETTING/PARTICIPANTS: Participants were women and men aged 18-40 years living in Queensland, Australia who owned a smartphone and had ≥2 skin cancer risk factors.

INTERVENTION

Participants were enrolled from December 2018 to February 2019 and completed an eligibility survey. Eligible participants were randomized to 4 different text message interventions using a Latin square design with varying personalization, interactivity, and message frequency (February 2019‒July 2019). Each intervention lasted for 1 month; between interventions, participants had a 1-week washout period in which they completed an online questionnaire. Participants completed a 6-month follow-up online survey in January 2020.

MAIN OUTCOME MEASURES

Measures included self-reported sun protection habits and sunburns.

RESULTS

A total of 277 (71.2% response rate) participants completed the 6-month follow-up. The sun protection habits index was significantly higher in all the 4 text messaging interventions (p<0.01 for each intervention) than at baseline, with similar sun protection habits improvements among all interventions (p=0.27). Sunburn rates decreased significantly over time (p<0.01 each intervention), with all the 4 interventions achieving reductions in sunburn rates during the intervention periods (p=0.78). Overall, the sunburn rates decreased from 40.3% at baseline to 7.0% at the end of the intervention, and at 6-month follow-up, it remained significantly below baseline levels at 23.5% (p<0.01).

CONCLUSIONS

Regular text messaging interventions result in significantly increased sun protection and decreased sunburn in young adults.

TRIAL REGISTRATION

This study is registered at the Australian and New Zealand Clinical Trials Registry ACTRN12618001299291.

摘要

介绍

短信是向有健康促进需求的人群传递信息的有效方式。本研究旨在确定最佳的短信干预措施,以改变有患皮肤癌风险的年轻成年人的行为。

研究设计

拉丁方交叉 RCT。

地点/参与者:参与者为年龄在 18-40 岁之间、居住在澳大利亚昆士兰州、拥有智能手机且有≥2 个皮肤癌风险因素的女性和男性。

干预措施

参与者于 2018 年 12 月至 2019 年 2 月进行入组筛选,并完成资格调查。符合条件的参与者通过拉丁方设计随机分配到 4 种不同的短信干预措施,这些措施在个性化、互动性和信息频率方面有所不同(2019 年 2 月至 2019 年 7 月)。每种干预措施持续 1 个月;在干预之间,参与者有 1 周的洗脱期,在此期间他们完成了在线问卷。参与者于 2020 年 1 月完成 6 个月的在线随访。

主要观察指标

包括自我报告的防晒习惯和晒伤情况。

结果

共有 277 名(71.2%的应答率)参与者完成了 6 个月的随访。与基线相比,所有 4 种短信干预措施的防晒习惯指数均显著升高(每项干预措施的 p<0.01),所有干预措施的防晒习惯改善情况相似(p=0.27)。晒伤率随时间显著下降(每个干预措施的 p<0.01),所有 4 种干预措施均在干预期间降低了晒伤率(p=0.78)。总体而言,晒伤率从基线时的 40.3%降至干预结束时的 7.0%,在 6 个月随访时仍显著低于基线水平(p<0.01)。

结论

定期的短信干预措施可显著提高年轻成年人的防晒意识并降低晒伤率。

试验注册

本研究在澳大利亚和新西兰临床试验注册中心注册,注册号为 ACTRN12618001299291。

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