聚焦超声治疗高危型人乳头瘤病毒感染相关宫颈病变的疗效。

Effectiveness of focused ultrasound for high risk human papillomavirus infection-related cervical lesions.

机构信息

State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China.

Department of Gynecology and Obstertrics, Affiliated Hospital of North Sichuan Medical College, Sichuan, China.

出版信息

Int J Hyperthermia. 2021 Sep;38(2):96-102. doi: 10.1080/02656736.2021.1910736.

DOI:10.1080/02656736.2021.1910736

PMID:34420437

Abstract

OBJECTIVE

The purpose of this study was to compare the efficacy of focused ultrasound (FU) and interferon drug therapy for cervical intraepithelial neoplasia 1 (CIN1) and chronic cervicitis associated with high risk human papillomavirus (HR-HPV) infection, as well as analyze the influencing factors.

METHODS

A retrospective cohort study was performed from January 2017 to December 2019. A total of 592 patients were enrolled, of which 300 patients were treated with FU and 292 patients were treated with interferon drugs. Kaplan-Meier curves and a COX regression model were used to compare the curative effects of the two therapeutic methods using HR-HPV clearance as the main outcome. The relationship between age, HR-HPV infection type, pathological type, preoperative HR-HPV status and HR-HPV clearance were also analyzed.

RESULTS

The median time for HR-HPV clearance was 6.00 months (95% CI: 5.24-6.76) in the FU group and 26.00 months (95% CI: 22.32-29.68) in the medication group. A significant difference was observed between the two groups (χ =198.902, = 0.000). The HR-HPV clearance rate was 4.927 (95% CI 3.840-6.321; = 0.000) times higher in the patients treated with FU than those treated with interferon drugs. In the FU group, no significant difference was observed in HR-HPV clearance rate between CIN1 and chronic cervicitis (χ=0.660, = 0.416), which was also insignificant between HR-HPV persistent and non-persistent infections (χ=0.751, = 0.386).

CONCLUSION

FU therapy can eliminate HR-HPV infections in a short period of time. Moreover, the treatment efficacy of FU was significantly superior to that of interferon drugs.

摘要

目的

本研究旨在比较聚焦超声（FU）与干扰素药物治疗宫颈上皮内瘤变 1 级（CIN1）和慢性宫颈炎合并高危型人乳头瘤病毒（HR-HPV）感染的疗效，并分析影响因素。

方法

回顾性队列研究，于 2017 年 1 月至 2019 年 12 月纳入 592 例患者，FU 组 300 例，干扰素组 292 例。以 HR-HPV 清除为主要结局，采用 Kaplan-Meier 曲线和 COX 回归模型比较两种治疗方法的疗效。分析年龄、HR-HPV 感染类型、病理类型、术前 HR-HPV 状态与 HR-HPV 清除的关系。

结果

FU 组 HR-HPV 清除中位时间为 6.00 个月（95%CI：5.24-6.76），药物组为 26.00 个月（95%CI：22.32-29.68），两组比较差异有统计学意义（χ=198.902， = 0.000）。FU 组 HR-HPV 清除率是干扰素组的 4.927 倍（95%CI 3.840-6.321； = 0.000）。FU 组中，CIN1 与慢性宫颈炎患者 HR-HPV 清除率差异无统计学意义（χ=0.660， = 0.416），HR-HPV 持续感染与非持续感染患者 HR-HPV 清除率差异也无统计学意义（χ=0.751， = 0.386）。