Turan, Uludağ University Child and Adolescent Psychiatry, Bursa, Turkey. Ermiş, Diyarbakır Children's Hospital, Diyarbakır, Turkey. Pereira-Sanchez, NYU Grossman School of Medicine, One Park Avenue, New York, USA. Tunctürk, Istanbul Bakirkoy Prof. Dr. Mazhar Osman Research and Training Hospital for Psychiatric and Neurological Diseases, Department of Child and Adolescent Psychiatry, Istanbul, Turkey.
Psychopharmacol Bull. 2021 Jun 1;51(3):10-26.
The current study evaluated the long-term effects of methylphenidate (MPH) discontinuation on growth parameters in Turkish children and adolescents with attention-deficit/hyperactivity disorder (ADHD).
432 children and adolescents (aged 6-18 years) with ADHD receiving MPH for at least 1 year between March 2012 and January 2019 were included in a retrospective cohort study. We analyzed weight, height, and body mass index (BMI) standard deviation z scores (SDS) of groups that either did (ADHD-C) or did not (ADHD-DC) discontinue MPH. Growth parameters were converted to z scores as normative values for the Turkish population to compare the measurements at baseline and the last follow-up visit by using the paired sample t-test.
In patients from the ADHD-C group, statistically significant negative correlations were found between age at starting MPH and differences in weight and height SDS between baseline and follow-up. Children had a greater reduction in weight and height compared to adolescents. When we evaluated the differences in pre-and post-treatment growth factors, we found no significant differences between the groups in terms of growth parameters.
Our data showed that chronic use of MPH was likely responsible for changes in height and weight parameters.
本研究评估了停止哌醋甲酯（MPH）治疗对土耳其注意缺陷多动障碍（ADHD）儿童和青少年生长参数的长期影响。
432 名年龄在 6-18 岁之间、接受至少 1 年 MPH 治疗的 ADHD 儿童和青少年（2012 年 3 月至 2019 年 1 月期间）被纳入回顾性队列研究。我们分析了继续（ADHD-C）或停止（ADHD-DC）MPH 治疗的两组的体重、身高和体重指数（BMI）标准差 z 评分（SDS）。生长参数转换为 z 评分，以土耳其人群的正常值进行比较，使用配对样本 t 检验比较基线和最后随访时的测量值。
在 ADHD-C 组的患者中，发现开始使用 MPH 的年龄与基线和随访时体重和身高 SDS 的差异之间存在显著负相关。儿童的体重和身高下降幅度大于青少年。当我们评估治疗前后生长因素的差异时，发现两组在生长参数方面没有显著差异。
我们的数据表明，MPH 的慢性使用可能导致身高和体重参数的变化。
