Lyu Li-Jiang, Mao Ling-Yu, Li Jing-Hu, Yang Chao, Wang Wei-Wa, Wang Sheng, Liu Ding
The Third Clinical Medical College of Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, Zhejiang, China.
Zhongguo Gu Shang. 2021 Aug 25;34(8):780-4. doi: 10.12200/j.issn.1003-0034.2021.08.017.
To observe the analgesic effect of lever positioning manipulation combined with pulsed electric field on patients with lumbar disc herniation and the influence on serum IL-1β and TNF-α.
From January 2018 to March 2019, 58 patients with lumbar disc herniation were included in the study, which were randomly divided into observation group and control group by digital table method. Observation group of 29 cases, including 16 males and 13 females, aged (38.03±11.29) years old, were treated with lever positioning manipulation combined with pulsed electric field. The 29 cases in control group, including 17 males and 12 females, aged (38.21±9.16) years old, were treated with pulsed electric field. Both groups of patients were treated 3 times a week, once every other day, 3 times as a course of treatment. After 2 courses of treatment, the two groups of patients were scored before and after treatment by the numeric rating scales (NRS);at the same time, the serum levels of IL-1β and TNF-α were measured before and after treatment.
The NRS scores of observation group and control group were 4.21±1.76, 4.66±1.61 before treatment, and 1.28±0.84, 2.10±1.35 after treatment, respectively. The NRS scores of the observation group after treatment was significantly lower than that of the control group (<0.05). After treatment, the concentrations of IL-1β and TNF-α in both groups became lower(<0.05). The levels of IL-1β in observation group and control group before treatment were (119.01±69.65), (112.23±78.43) pg /ml, and after treatment were (59.78±36.60), (77.51±40.46) pg/ml, respectively. The levels of TNF-α in observation group and control group before treatment were (1.68± 1.13), (1.74±0.70) pg /ml, and after treatment were (1.14±0.56), (1.45±0.58) pg /ml, respectively. The change of IL-1β and TNF-α in observation group was better than that in control group (<0.05).
The lever positioning manipulation combined with pulsed electric field has a good analgesic effect on patients with lumbar disc herniation, and it has a significant impact on the patient's serum IL-1β and TNF-α concentration, which can be used as a clinical guide. However, the synergistic effect of lever positioning technique combined with pulsed electric field and guidelines for clinical treatment need further research.
观察杠杆定位手法联合脉冲电场对腰椎间盘突出症患者的镇痛效果及对血清白细胞介素-1β（IL-1β）和肿瘤坏死因子-α（TNF-α）的影响。
选取2018年1月至2019年3月收治的58例腰椎间盘突出症患者纳入研究，采用数字表法随机分为观察组和对照组。观察组29例，男16例，女13例，年龄（38.03±11.29）岁，采用杠杆定位手法联合脉冲电场治疗。对照组29例，男17例，女12例，年龄（38.21±9.16）岁，采用脉冲电场治疗。两组患者均每周治疗3次，隔日1次，3次为1个疗程。治疗2个疗程后，采用数字分级量表（NRS）对两组患者治疗前后进行评分；同时检测治疗前后血清IL-1β和TNF-α水平。
观察组和对照组治疗前NRS评分分别为4.21±1.76、4.66±1.61，治疗后分别为1.28±0.84、2.10±1.35。观察组治疗后NRS评分显著低于对照组（<0.05）。治疗后，两组IL-1β和TNF-α浓度均降低（<0.05）。观察组和对照组治疗前IL-1β水平分别为（119.01±69.65）、（112.23±78.43）pg/ml，治疗后分别为（59.78±36.60）、（77.51±40.46）pg/ml。观察组和对照组治疗前TNF-α水平分别为（1.68±1.13）、（1.74±0.70）pg/ml，治疗后分别为（1.14±0.56）、（1.45±0.58）pg/ml。观察组IL-1β和TNF-α的变化优于对照组（<0.05）。
杠杆定位手法联合脉冲电场对腰椎间盘突出症患者有良好的镇痛效果，对患者血清IL-1β和TNF-α浓度有显著影响，可作为临床指导。然而，杠杆定位技术联合脉冲电场的协同作用及临床治疗指南有待进一步研究。
