Radel S, Mayhew E, Rustum Y M
Department of Experimental Pathology, Roswell Park Memorial Institute, Buffalo, N.Y. 14263.
Anticancer Res. 1987 Nov-Dec;7(6):1105-8.
The calcium channel blockers 'DMDP' [N-3,4-dimethoxyphenethyl)-N-methyl-2-(2-naphthyl-m-dithane-2-prop ylamine)] and verapamil inhibited the active efflux of adriamycin from adriamycin-resistant P388 leukemia cells but had no effect on the drug-sensitive cell line. However, after removal of the calcium channel blockers, DMDP at a low drug concentration caused a much longer inhibition of this efflux pathway than verapamil. This may be attributed to the higher binding affinity of DMDP for receptor sites.
钙通道阻滞剂“DMDP”[N-（3,4-二甲氧基苯乙基）-N-甲基-2-（2-萘基间二硫戊环-2-丙胺）]和维拉帕米抑制了阿霉素从耐阿霉素的P388白血病细胞中的主动外排，但对药物敏感细胞系没有影响。然而，在去除钙通道阻滞剂后，低药物浓度的DMDP对这种外排途径的抑制作用比维拉帕米长得多。这可能归因于DMDP对受体位点的更高结合亲和力。
