在用钙拮抗剂和钙调蛋白抑制剂孵育后，耐药P388肿瘤细胞中长春新碱和阿霉素的积累增加。
Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.
作者信息
Tsuruo T, Iida H, Tsukagoshi S, Sakurai Y
出版信息
Cancer Res. 1982 Nov;42(11):4730-3.
PMID:7127307
Abstract
Some calcium antagonists and calmodulin inhibitors enhance the intracellular levels of vincristine and Adriamycin in vincristine- and Adriamycin-resistant P388 leukemia cells by inhibiting their outward transport. The high intracellular drug accumulation was directly related to the enhancement of the cytotoxicity of the antitumor agents, and the vincristine and Adriamycin resistance in these cells was circumvented.
摘要
一些钙拮抗剂和钙调蛋白抑制剂通过抑制长春新碱和阿霉素耐药的P388白血病细胞向外转运，提高细胞内长春新碱和阿霉素的水平。细胞内药物的高蓄积与抗肿瘤药物细胞毒性的增强直接相关，这些细胞对长春新碱和阿霉素的耐药性被克服。
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