Department of Dermatology and Venereology, The First Affiliated Hospital of USTC.
Department of Urological Surgery, The First Affiliated Hospital of USTC, Hefei, Anhui, China.
Photodiagnosis Photodyn Ther. 2021 Dec;36:102496. doi: 10.1016/j.pdpdt.2021.102496. Epub 2021 Aug 21.
Condylomata acuminata (CA) caused by human papillomavirus, often involves the external genitalia, perianal skin, and other moist mucous membranes. Urethral involvement is uncommon and little recognized, and usually limited to the distal 3 cm of the meatus. It is difficult to treat CA involving the urethra because of the anatomical location, risk of complications and recurrence. One effective method for the treatment of CA located at the urinary meatus is 5-aminolevulinic acid photodynamic therapy (ALA-PDT). However, experience of using this method for the treatment of whole urethral CA is still very limited. Herein, we treated a whole urethral CA successfully with photodynamic and holmium laser therapies. The case of a 25-year-old patient who underwent kidney transplant effected by intraurethral CA is presented and discussed. Catheter implantation and (or) immunosuppression treatment increases the risk of urethral condyloma acuminatum. The ALA-PDT is a safe, straightforward, effective, and well-tolerated treatment procedure for intraurethral CA. ALA-PDT combined with holmium laser treatment can successfully treat kidney transplant patients with intraurethral CA.
人乳头瘤病毒引起的尖锐湿疣（CA）常累及外生殖器、肛周皮肤和其他湿润的黏膜。尿道受累并不常见，也很少被认识到，通常局限于尿道口的远端 3cm 内。由于解剖位置、并发症和复发的风险，治疗尿道内的 CA 很困难。5-氨基酮戊酸光动力疗法（ALA-PDT）是治疗尿道口 CA 的有效方法之一。然而，用这种方法治疗整个尿道 CA 的经验仍然非常有限。本文报告并讨论了我们用光动力和钬激光联合治疗一例全尿道 CA 的病例。尿道内 CA 可发生于行移植肾术后的患者，留置导尿和（或）免疫抑制治疗增加了尿道尖锐湿疣的风险。ALA-PDT 是一种安全、简单、有效、耐受良好的治疗尿道内 CA 的方法。ALA-PDT 联合钬激光治疗可成功治疗移植肾患者的尿道内 CA。
