Li Jie, Yi Yunlian, Zhu Wu
Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2011 Nov;36(11):1115-9. doi: 10.3969/j.issn.1672-7347.2011.11.015.
To observe the effect of the three stages of 5-aminolevulinic acid-photodynamic therapy (ALA-PDT) on condyloma acuminatum of external urethral meatus.
A total of 56 patients with condyloma acuminatum of external urethral meatus presenting at the Department of Dermatology of Xiangya Hospital from Janunary 2009 to September 2009 were randomly treated by the three stages of ALA-PDT. The topical ALA followed by PDT was carried out once a week for 3 weeks. Rates of cure, ineffectiveness, adverse effects and complications were observed. The follow-up time was 6 months and the recurrence rates were documented.
After treatment of three stages of ALA-PDT, complete remission was achieved in 48 out of the 56 patients (85.7%). The recurrence rate was 14.3% (8 cases), and 2 patients had no responses (3.6%). Only 1 patient had serious pain during the treatment, and the rate of adverse effect was 1.8%. No complications were observed.
The three stages of ALA-PDT are safe, effective and tolerant treatment for condyloma acuminatum of external urethral meatus.
观察5-氨基酮戊酸光动力疗法（ALA-PDT）三个阶段对外尿道口尖锐湿疣的治疗效果。
选取2009年1月至2009年9月在湘雅医院皮肤科就诊的56例外尿道口尖锐湿疣患者，随机采用ALA-PDT三个阶段进行治疗。外用ALA后进行光动力治疗，每周1次，共3周。观察治愈率、无效情况、不良反应及并发症。随访时间为6个月，并记录复发率。
经ALA-PDT三个阶段治疗后，56例患者中48例（85.7%）完全缓解。复发率为14.3%（8例），2例患者无反应（3.6%）。仅1例患者在治疗期间出现严重疼痛，不良反应发生率为1.8%。未观察到并发症。
ALA-PDT三个阶段对外尿道口尖锐湿疣是一种安全、有效且耐受性良好的治疗方法。
