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基因不同的霍奇金淋巴瘤与原发性纵隔淋巴瘤同时发生。

Concomitant occurrence of genetically distinct Hodgkin lymphoma and primary mediastinal lymphoma.

作者信息

Dubois Sydney, Ruminy Philippe, Bohers Elodie, Viailly Pierre-Julien, Veresezan Liana, Picquenot Jean-Michel, Bobée Victor, Viennot Mathieu, Penther Dominique, Camus Vincent, Thieblemont Catherine, Pouaty Camille, Tilly Hervé, Jardin Fabrice

机构信息

Department of Clinical Hematology Centre Henri Becquerel, INSERM U1245 Rouen France.

CHU Charles Nicolle Rouen France.

出版信息

Clin Case Rep. 2021 Aug 16;9(8):e04504. doi: 10.1002/ccr3.4504. eCollection 2021 Aug.

DOI:10.1002/ccr3.4504
PMID:34429980
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8365538/
Abstract

Synchronous Hodgkin Lymphoma and Primary Mediastinal B-cell Lymphoma is possible, with molecular analyses proving the absence of clonal filiation between both entities. This suggests a common etiology but the existence of two divergent clones.

摘要

同步发生霍奇金淋巴瘤和原发性纵隔B细胞淋巴瘤是有可能的，分子分析证实这两种实体之间不存在克隆关系。这表明存在共同病因，但有两个不同的克隆。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7352/8365538/3032cd3ec1eb/CCR3-9-e04504-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7352/8365538/a7df2448281e/CCR3-9-e04504-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7352/8365538/de079c311708/CCR3-9-e04504-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7352/8365538/3032cd3ec1eb/CCR3-9-e04504-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7352/8365538/a7df2448281e/CCR3-9-e04504-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7352/8365538/de079c311708/CCR3-9-e04504-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7352/8365538/3032cd3ec1eb/CCR3-9-e04504-g001.jpg

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本文引用的文献

1
PET-adapted treatment for newly diagnosed advanced Hodgkin lymphoma (AHL2011): a randomised, multicentre, non-inferiority, phase 3 study.PET 指导下治疗新诊断的晚期霍奇金淋巴瘤（AHL2011）：一项随机、多中心、非劣效性、3 期研究。
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Determination of Molecular Subtypes of Diffuse Large B-Cell Lymphoma Using a Reverse Transcriptase Multiplex Ligation-Dependent Probe Amplification Classifier: A CALYM Study.采用逆转录多重连接依赖探针扩增分类器测定弥漫性大 B 细胞淋巴瘤的分子亚型：CALYM 研究。
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Next-Generation Sequencing in Diffuse Large B-Cell Lymphoma Highlights Molecular Divergence and Therapeutic Opportunities: a LYSA Study.
弥漫性大 B 细胞淋巴瘤中的下一代测序凸显了分子差异和治疗机会：LYSA 研究。
Clin Cancer Res. 2016 Jun 15;22(12):2919-28. doi: 10.1158/1078-0432.CCR-15-2305. Epub 2016 Jan 27.
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Identification of Primary Mediastinal Large B-cell Lymphoma at Nonmediastinal Sites by Gene Expression Profiling.通过基因表达谱分析在非纵隔部位鉴定原发性纵隔大B细胞淋巴瘤
Am J Surg Pathol. 2015 Oct;39(10):1322-30. doi: 10.1097/PAS.0000000000000473.
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PET-adapted sequential salvage therapy with brentuximab vedotin followed by augmented ifosamide, carboplatin, and etoposide for patients with relapsed and refractory Hodgkin's lymphoma: a non-randomised, open-label, single-centre, phase 2 study.PET 适应序贯挽救治疗，采用 Brentuximab Vedotin 继以增强异环磷酰胺、卡铂和依托泊苷，用于复发和难治性霍奇金淋巴瘤患者：一项非随机、开放标签、单中心、2 期研究。
Lancet Oncol. 2015 Mar;16(3):284-92. doi: 10.1016/S1470-2045(15)70013-6. Epub 2015 Feb 13.
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Does rituximab have a place in treating classic hodgkin lymphoma?利妥昔单抗在治疗经典型霍奇金淋巴瘤中有一席之地吗？
Curr Hematol Malig Rep. 2010 Jul;5(3):135-9. doi: 10.1007/s11899-010-0052-z.
7
Mediastinal gray zone lymphoma: the missing link between classic Hodgkin's lymphoma and mediastinal large B-cell lymphoma.纵隔灰色地带淋巴瘤：经典霍奇金淋巴瘤与纵隔大B细胞淋巴瘤之间缺失的环节。
Am J Surg Pathol. 2005 Nov;29(11):1411-21. doi: 10.1097/01.pas.0000180856.74572.73.
8
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J Exp Med. 2003 Sep 15;198(6):851-62. doi: 10.1084/jem.20031074.
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Non-Hodgkin's lymphoma after primary Hodgkin's disease in the German Hodgkin's Lymphoma Study Group: incidence, treatment, and prognosis.德国霍奇金淋巴瘤研究组中，原发性霍奇金病后发生的非霍奇金淋巴瘤：发病率、治疗及预后
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Molecular features of primary mediastinal B-cell lymphoma: involvement of p16INK4A, p53 and c-myc.原发性纵隔B细胞淋巴瘤的分子特征：p16INK4A、p53和c-myc的参与情况
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