Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.
NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin 300134, China.
ACS Appl Mater Interfaces. 2021 Aug 25;13(33):38979-38989. doi: 10.1021/acsami.1c08132. Epub 2021 Aug 16.
Chronic infections caused by pose severe threats to human health. Traditional antibiotic therapy has lost its total supremacy in this battle. Here, nanoplatforms activated by the clinical microenvironment are developed to treat infection on the basis of dynamic borate ester bonds. In this design, the nanoplatforms expose targeted groups for bacterial capture after activation by an acidic infection microenvironment, resulting in directional transport delivery of the payload to bacteria. Subsequently, the production of hyperpyrexia and reactive oxygen species enhances antibacterial efficacy without systemic toxicity. Such a formulation with a diameter less than 200 nm can eliminate biofilm up to 75%, downregulate the level of cytokines, and finally promote lung repair. Collectively, the biomimetic design with phototherapy killing capability has the potential to be an alternative strategy against chronic infections caused by .
由 引起的慢性感染对人类健康构成严重威胁。在这场战斗中，传统的抗生素疗法已经失去了绝对优势。在这里，基于动态硼酸酯键，开发了由临床微环境激活的纳米平台来治疗 感染。在该设计中，纳米平台在酸性感染微环境激活后暴露出靶向基团以用于细菌捕获，从而实现了有效载荷对细菌的定向转运递送。随后，高热和活性氧的产生增强了抗菌功效而没有全身毒性。这种直径小于 200nm 的制剂可以消除高达 75%的生物膜，下调细胞因子水平，最终促进肺部修复。总之，具有光疗杀伤能力的仿生设计有可能成为治疗由 引起的慢性感染的替代策略。
