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盒状嗜盐古菌中华盐盒菌ATCC 33800的全基因组和甲基化组分析

Complete Genome and Methylome Analysis of the Box-Shaped Halophilic Archaeon Haloarcula sinaiiensis ATCC 33800.

作者信息

Fomenkov Alexey, DasSarma Priya, Kennedy Sean P, Roberts Richard J, DasSarma Shiladitya

机构信息

Research Department, New England BioLabs, Ipswich, Massachusetts, USA.

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

出版信息

Microbiol Resour Announc. 2021 Aug 26;10(34):e0061921. doi: 10.1128/MRA.00619-21.

Abstract

The genome of halophilic archaeon Haloarcula sinaiiensis ATCC 33800 was sequenced and assembled and comprises seven replicons. Four m6A and one m4C modified motifs and their responsible methyltransferase genes have been identified in the genome by single-molecule real-time (SMRT) sequencing and bioinformatic analysis.

摘要

对嗜盐古菌中华盐盒菌(Haloarcula sinaiiensis)ATCC 33800的基因组进行了测序和组装,其基因组由七个复制子组成。通过单分子实时(SMRT)测序和生物信息学分析,在该基因组中鉴定出了四个N6-甲基腺苷(m6A)和一个N4-甲基胞嘧啶(m4C)修饰基序及其相应的甲基转移酶基因。

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